re: Anyone here have any transgendered friends?

It's a valid point. I mean, I would likely try and maintain the friendship, but this is big stuff. If you became best friends with a straight guy or a guy at all, and you later learn he's gay or he's becoming a woman, that may or may not be the same person you were friends with.

Obviously if a friend told you he was gay and continued to be largely the same, then it doesn't make sense that it'd have to screw up the friendship. But if his life becomes about "being gay" (gay bars, restaurants, friends, etc) that's a huge thing you don't have in common.

I've seen it happen a few times with families, where a guy's sister or other family member really struggles with it. Some people would probably criticize it for her, but people grow up envisioning something, like having a sister in law, and then it doesn't happen. It's a big thing and while certainly not the fault of the person coming out, I can't blame the person struggling with the adjustment either.