re: One step closer to tying homosexuality to the human genome

quote:

---

To be fair, you first reasonded with "nope, doesn't change." You basically took a stab at it the first time, adjusted your answer with every response from me and then pretend I'm the one playing gotcha.

---

I said nope to what?

quote:

---

So there are common mutations for smoking.

---

Ok, its obvious that you don't really understand and you are just googling and pasting. I will try again to illustrate my point as simply as possible. If you still don't get it, I can't help you because I got stuff to do tonight.

From your quote:

quote:

---

“Smoking gun” K-ras and p53 are the two genes most frequently mutated in smoking-related lung cancers.

---

What I bolded is key, and is why your statement that:

quote:

---

So there are common mutations for smoking.

---

...is incorrect. For those who have a particular phenotype of "smoking related cancer" their are similarities in genetic mutations. But that does not mean smoking doesn't cause global genomic issues. Its just that IF smoking hits p53 and k-ras--two KEY enzymes in protecting the integrity of the genome--than one is more likely to have increased DNA replication mutations globally, leading to the phenotype of cancer. When smoking causes mutations at other "less important" sites--which it invariably does--one does not get cancer. But I repeat--that doesn't mean smoking goes straight to p53 and kras and leaves everything else alone. I understand how that can be confusing for you if you are simply googling and don't have much understanding of genetic processes.

This is one explanation as to why alot of people who have smoked for decades have never had cancer--the smoking did not lead to mutation of the right key genes. It did lead to other mutations, I can promise you that.