re: Is it possible to go too low and slow?

You must have a pellet grill/smoker. I used to start most things on my RecTeq at 180 for a few hours before turning it up to 200+. Now that I've added a Smokai to the rig, there is more than enough smoke at any tmep. I'd recommend looking into one of those if you need more smoke.

As to your question, here is a thread on the subject from the SmokingMeats forum.