Green Zones Within French Quarter

Some people I know are going to New Orleans later this year and are staying at the Omni Royal in the French quarter. Can y’all give me some streets/areas to tell them to stay away from to not 100% get murdered? I haven’t been in the French quarter in years so have no idea and know they’ll ask me even though I’m nowhere near New Orleans. They already know that the chance they are murdered is > 90%