re: What would be Mississippi State's overall reputation as a university be?

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I don't know where they land in the USNWR rankings, but I think MSU is probably a top 100 research university by any reasonable standard.

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#216

When you get outside the top 40 or so the individual major matters much more than the overall number.

While this is a grad school example it shows how important course of study is when ranking schools.

The University of South Carolina is ranked #124 but the MBA program is ranked #55 but the International Business specialty is ranked #1 in the nation.