re: 1/2 ton diesel engines

I haven’t looking into this in years, but has anyone tried to “hypermile” some of these new truck/ engine combos? The guys that use trucks like a fairly normal residential home guy- drive normal, tow a boat on the weekend, put it in 4x4 thrice a year when it rains at the camp, etc.

Im talking tune, program, right tires, etc to get the best gas mileage possible? I’d be curious what the 3.0 would do compared to say they Ford 2.7 EB.