Slay the Spire is Simply Awesome

Good point. From what I've read of interviews with the developers (told you I was hooked), it seems very unlikely that they'll ever go this route. As it stands now, it already plays like a finished game without anything like microtransactions.

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Am I correct that you don't permanently collect cards a la hearthstone?

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Yes. There are a few gated unlocks of new cards to be found, but your deck always starts the same.

There aren't a lot of chances to transform cards. Honestly, it's usually not all that beneficial because so many cards are only good in certain types of decks. I don't want to give too many tips because it's a lot of fun figuring it out on your own, but I will say that it helps to be very selective with your card choices once you figure out a few strategies that work. Also, remove a strike or defend at just about every shop. It's worth the cost because it helps you cycle through your deck faster and find your key cards.

It doesn't get harder every time unless you start playing in ascension mode (this goes all the way to 15 so it can be extremely challenging), but sometimes everything just comes together perfectly, you have a great run, and then you lose a bunch of games in a row. That's rng for you.