First pick in a keeper league draft help please

10 team league, non-PPR, have to start 2 running backs and 3 wide receivers:


Any way, we keep 3 guys and there's no limit for how long you can keep a player. My three keepers are:

QB - Andrew Luck
RB - Jay Ajayi
WR - DeAndre Hopkins


Here's a list of the players being kept:

QB

Andrew Luck
Aaron Rodgers
Drew Brees

RB

David Johnson
LeSean McCoy
C.J. Anderson
Jay Ajayi
Ezekiel Elliott
Lamar Miller
Melvin Gordon
Todd Gurley
Le’Veon Bell
DeMarco Murray
Devonta Freeman
Carlos Hyde
Jordan Howard

WR

Demaryius Thomas
Julio Jones
Odell Beckham
DeSean Jackson
DeAndre Hopkins
Amari Cooper
Michael Thomas
A.J. Green
Jordy Nelson
Antonio Brown
Dez Bryant
Mike Evans

TE

Greg Olsen
Rob Gronkowski



So... is Leonard Fournette the obvious and correct choice here? I'm worried about his foot injuries. Am I overthinking it?

The best running backs that I see available are Fournette, Crowell, Lynch, Mixon, McCaffrey, and Cook. I'd prefer to grab one of the rookies over Crowell and Lynch but I'm worried that Hill will still be a thorn in the side of Mixon, Stewart will take away carries from McCaffrey, and I don't know what to think of Cook.