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re: Diamond in the Rough - Humanigen ($HGEN) a little DD
Posted on 2/1/21 at 12:06 pm to itsbigmikey
Posted on 2/1/21 at 12:06 pm to itsbigmikey
Here's a link to a Mayo Clinic case study from November and some snippets. LINK
"In high-risk COVID-19 patients with severe pneumonia, granulocyte-macrophage colony-stimulating factor neutralization with lenzilumab was safe and associated with faster improvement in clinical outcomes, including oxygenation, and greater reductions in inflammatory markers compared with a matched control cohort of patients hospitalized with severe COVID-19 pneumonia. A randomized, placebo-controlled clinical trial to validate these findings is ongoing (NCT04351152)."
"Lenzilumab has been studied across four completed clinical trials in healthy volunteers and patients with asthma, rheumatoid arthritis, and chronic myelomonocytic leukemia.23,24 A total of 113 individuals received lenzilumab in these trials. Lenzilumab was well tolerated with a low frequency and severity of adverse events.23,24"
"In high-risk COVID-19 patients with severe pneumonia, granulocyte-macrophage colony-stimulating factor neutralization with lenzilumab was safe and associated with faster improvement in clinical outcomes, including oxygenation, and greater reductions in inflammatory markers compared with a matched control cohort of patients hospitalized with severe COVID-19 pneumonia. A randomized, placebo-controlled clinical trial to validate these findings is ongoing (NCT04351152)."
"Lenzilumab has been studied across four completed clinical trials in healthy volunteers and patients with asthma, rheumatoid arthritis, and chronic myelomonocytic leukemia.23,24 A total of 113 individuals received lenzilumab in these trials. Lenzilumab was well tolerated with a low frequency and severity of adverse events.23,24"
Posted on 2/1/21 at 12:19 pm to itsbigmikey
Interesting, and good luck to you. Just so others are aware, 5 other anti-GM-CSF monoclonals are in also clinical trials in covid patients. Online accessible reference: Nature Rev Immunol 20:507-514; 2020.
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