New Home Purchase Mortgage scenarios: Seeking Input

Buying new home -- the final one so says our plan...!

Context:

I am 18 yrs w/company. Plan to work 12 - 15 yrs more w/company

However, wife & I took a life decision: no more relos so this is it. This decision puts me at risk of exiting company in 5 or so yrs making significantly less $ upon exit.

Married w/2 kids in grade school. Wife is stay at home Mom and college educated--ready to enter work place if I need to exit -- worst case.

Have planned for this so we have saved for their private school that covers them through high school. Their college 529s will be funded to our target $ in next 3-yrs. Have daughter's wedding savings nearly funded, albeit bologna sandwiches and Olympia beer level! Kidding.

To the mortgage scenario:
30-yr fixed mortgage at 4.125%
Can put down: 20 - 50%

If 20%, would invest balance of 30%. to target > 4.125% return. This scenario would stress home budget if exit company in 5-yrs.

If 50%, would regret opportunity to invest. Although, after 2008, having shifted thinking to more $ in hard assets.

Given key risks of economy, interest rates propensity up, inflation, and job scenario...

Seeking TD input. Much appreciated...