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re: Statins for cholesterol? Yes or No
Posted on 8/28/23 at 10:04 am to Earnest_P
Posted on 8/28/23 at 10:04 am to Earnest_P
quote:
How does LDL cause artherosclerosis?
LDL enters through endothelial injury sites, specifically areas with disturbed laminar or turbulent flow, which reduces wall sheer stress of vessels and promotes LDL infiltration along with endothelial dysfunction. The original source of the dysfunction is chronic stress on endothelium through arterial hypertension. Macrophages and smooth muscle cells (stimulated to move to injury sites by PDGF) ingest cholesterol carried by oxidized LDL and transform into foam cells, lipid-laden macrophages which form fatty streaks, which is the first sign of atherosclerosis.
2
Posted on 8/28/23 at 10:16 am to crazy4lsu
quote:
LDL enters through endothelial injury sites, specifically areas with disturbed laminar or turbulent flow, which reduces wall sheer stress of vessels and promotes LDL infiltration along with endothelial dysfunction. The original source of the dysfunction is chronic stress on endothelium through arterial hypertension. Macrophages and smooth muscle cells (stimulated to move to injury sites by PDGF) ingest cholesterol carried by oxidized LDL and transform into foam cells, lipid-laden macrophages which form fatty streaks, which is the first sign of atherosclerosis.
Main cause of the above: inflammation, main cause of inflammation excess sugar and carbohydrates. Fact.
Posted on 8/28/23 at 12:36 pm to crazy4lsu
Statins reduce mace by 1-2% ARR and relative is 25%, can you explain what the RRR is relative to. Also people want to condemn a low 1% arr, but this is for only 2.5 years. What do the studies say about mace reduction when on statins on for decades?
I saw a study that said most people who have heart attacks have low cholesterol. To many that means they don’t work, but I imagine much to the contrary can be extracted from that.
There is an old drug, bempedoic acid, without all the muscle side effects that has recently shown just as effective as statins.
Also glp1 inhibitors showing as effective as statins, probably a lot from just weight loss, and many who favor a certain diet to reduce ldl, it’s likely from weight loss.
I saw a study that said most people who have heart attacks have low cholesterol. To many that means they don’t work, but I imagine much to the contrary can be extracted from that.
There is an old drug, bempedoic acid, without all the muscle side effects that has recently shown just as effective as statins.
Also glp1 inhibitors showing as effective as statins, probably a lot from just weight loss, and many who favor a certain diet to reduce ldl, it’s likely from weight loss.
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