re: I am TIRED AND FRUSTRATED with my friends wife flirting with me.

I would ignore it. I would also spark a conversation with the husband, while his wife was listening about a friend of yours that got caught messing with another man's wife. And that you would never even think about cheating on your wife, period. Just a casual conversation with him. That lets his wife know you're not interested. You confront her and there's no telling what she may do.