re: No. 1 Seeds are 2-33 at winning CWS Title

2022: Ole Miss (NR, 3-seed in #6 Miami Regional)
2021: Mississippi State (7)
2019: Vandy (2)
2018: Oregon State (3)
2017: Florida (3)
2016: Coastal Carolina (NR, 2-seed in NC State Regional paired with #8 LSU)
2015: Virginia (NR, 3-seed in UCSB Regional paired with #1 UCLA)
2014: Vandy (NR, Regional host paired with #4 Indiana)
2013: UCLA (NR, Regional host paired with #5 Cal State Fullerton)
2012: Arizona (NR, Regional host paired with #6 North Carolina)
2011: South Carolina (4)
2010: South Carolina (NR, Regional host, paired with #4 Coastal Carolina)
2009: LSU (3)
2008: Fresno State (NR, 4-seed in Long Beach State Regional, paired with #3 Arizona State)
2007: Oregon State (NR, 3-seed in Virginia Regional, paired with #1 Vandy)
2006: Oregon State (NR, Regional host, paired with #3 Texas)
2005: Texas (NR, Regional host, paired with #5 Ole Miss)
2004: Cal State Fullerton (NR, 2-seed at #7 Arizona State regional)
2003: Rice (5)
2002: Texas (5)

So, in the past 20 seasons:
#1: 0
#2: 1
#3: 3
#4: 1
#5: 2
#6: 0
#7: 1
#8: 0
Regional Host: 6
Non-regional Host: 6

Just goes to show that anything can happen. Recent trend says the best spot is in the #2,3,6,7 side of the bracket.