Lenzilumab dd from Humanigen’s website

This a good summary of Lenz. Phase 3 readout within the next 2 weeks. Positive results will most likely lead to EUA and this stock could 3-5x quickly (and maybe a Gilead buyout?). Nothing from my dd leads me to believe the trial will not be successful.

A recent UK study at the Imperial College London has further emphasized the importance of stopping “cytokine storm”

quote:
In an analysis of more than 500 COVID-19 patients across the UK, researchers identified several inflammatory markers in blood which increased within the early stages of COVID-19 in those who went on to become critically ill. One marker in particular, a cytokine called GM-CSF, was found at higher levels in those who later progressed to severe disease, compared to healthy controls or those with influenza, and was found to be almost 10 times higher in those who died from COVID-19.

Also, Humanigen just secured an $80,000,000 loan from Hercules Capital to bolster manufacturing of lenz... BEFORE the phase 3 readout. Hmmm, quite a risky move if you aren’t expecting positive results. From business wire:

quote:
The term loan facility provides working capital to support the production of lenzilumab, strengthens our balance sheet and increases our financial flexibility as we prepare for the potential Emergency Use Authorization and commercial launch of lenzilumab in 2021,” said Cameron Durrant, MD, MBA, Chief Executive Officer, Humanigen. The facility consists of a $25 million initial term loan, with up to an additional $55.0 million available for future draws subject to achievement of future milestones and satisfaction of other conditions. The facility provides for an interest-only period and the four-year term is extendable under certain conditions. Loans under the facility are secured by the company’s assets.

Anything under $20 is more than solid IMO and I’ve averaged down quite a bit over the last two weeks. Call premiums are high but could pay bigly on positive results. These next two weeks should be interesting!