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Started By
Message
Human Gene Therapy
Posted on 5/20/14 at 9:10 pm
Posted on 5/20/14 at 9:10 pm
Where are we with this science?
The University of Florida cured mice with my
eye disease in 2005, yet nothing has come of it. LINK
With over $600 million invested during the past 12 months,
it seems like people may get relief soon.
What other SEC schools have a genetics institute?
Has the medical community had
more of a free hand under the current government for research?
Thanks for any positive or constructive answers.
The University of Florida cured mice with my
eye disease in 2005, yet nothing has come of it. LINK
With over $600 million invested during the past 12 months,
it seems like people may get relief soon.
What other SEC schools have a genetics institute?
Has the medical community had
more of a free hand under the current government for research?
Thanks for any positive or constructive answers.
Posted on 5/20/14 at 9:25 pm to Hater Bait
Not even one response.
I guess we haven't advanced very far.
I guess we haven't advanced very far.
Posted on 5/20/14 at 9:28 pm to Hater Bait
Rats are one thing.
Doing it in humans is another.
IMO the big thing holding it back is the massive amount of regulation of human testing. Who would want to volunteer for genetic testing that could give you super aids cancer?
Doing it in humans is another.
IMO the big thing holding it back is the massive amount of regulation of human testing. Who would want to volunteer for genetic testing that could give you super aids cancer?
This post was edited on 5/20/14 at 9:30 pm
Posted on 5/20/14 at 9:30 pm to SundayFunday
If we have definitive proof of someone being a child molester, rapist or murderer, I'd be ok with testing various treatments and stuff on them.
Posted on 5/20/14 at 9:32 pm to Hater Bait
The good news is that it still seems very promising. The bad news is that we are still far away from making it commonplace. Every small step takes years of work.
Posted on 5/20/14 at 9:33 pm to SundayFunday
quote:
Who would want to volunteer for genetic testing that could give you super aids cancer?
I would volunteer my left eye.
It's basically dead anyway, but I don't want
to do something foolish like inject Super AIDS Cancer.
However, I'll take whatever that blind Florida Rat got.
He can see.
Posted on 5/20/14 at 9:36 pm to Hater Bait
These things need more time and more money.
Posted on 5/20/14 at 9:39 pm to Winkface
quote:
The good news is that it still seems very promising. The bad news is that we are still far away from making it commonplace. Every small step takes years of work.
I'm running out of time.
Lord , God, I hope this country stays ahead of the medical curve.
Forget the f****** politics.
Posted on 5/20/14 at 9:44 pm to Hater Bait
Do you keep up with clinical trials? See if you are eligible?
Posted on 5/20/14 at 9:46 pm to Hater Bait
Thank the FDA for the ridiculous bullshite. In order to launch even the most simple of pharmaceutical/medical products, you've got to invest at least a half a billion dollars, and that's pretty much the bare minimum. They make companies do billions upon billions in research, and if there is a minute flaw, then they hose it and make you start over again.
This post was edited on 5/20/14 at 10:06 pm
Posted on 5/20/14 at 9:48 pm to OMLandshark
And if they didn't, it went to the public and somebody got hurt, you'd be screaming negligence.
Posted on 5/20/14 at 9:48 pm to Winkface
quote:
Do you keep up with clinical trials? See if you are eligible
I've tried everything.
University of Michigan is the only system that really has done any trials.
I tried the acid eye drops, they helped somewhat.
But, my goodness, the pain, with very little improvement.
My best bet may be Europe.
Posted on 5/20/14 at 9:50 pm to Winkface
quote:
And if they didn't, it went to the public and somebody got hurt, you'd be screaming negligence.
Knowing the pain of launching a product, it can be pretty ridiculous on how much it costs. Sure, I'd say this needs at least half a billion in testing, but a pink eye drop? Please.
Posted on 5/20/14 at 9:56 pm to OMLandshark
quote:
Thank the FCC
You mean FDA?
The lawyers hamper positive movement.
I'm sorry , but if we are going to move forward, there will be some sad souls that are hurt.
I'm willing to be one for the advancement of the health of mankind. I'm not talking about something completely foolish, but I understand people may be hurt.
I just don't want to do nothing.
Posted on 5/20/14 at 10:01 pm to OMLandshark
quote:
pink eye drop? Please.
Pink eye and going blind are two fricking different things.
Posted on 5/20/14 at 10:01 pm to Hater Bait
Have you read about the Human Microbiome Project?
LINK
Eta: Doubt this helps with going blind, but it's somewhat relevant.
LINK
quote:
Examinations of DNA sequences served as the equivalent of an old-time microscope, said Curtis Huttenhower of the Harvard School of Public Health, an investigator for the microbiome project. They allowed investigators to see — through their unique DNA sequences — footprints of otherwise elusive bacteria.
Eta: Doubt this helps with going blind, but it's somewhat relevant.
This post was edited on 5/20/14 at 10:03 pm
Posted on 5/20/14 at 10:05 pm to Hater Bait
quote:
You mean FDA?
God damnit, yes. I just hate the FCC even more to where that was the first one that popped in my head.
quote:
The lawyers hamper positive movement.
I'm sorry , but if we are going to move forward, there will be some sad souls that are hurt.
I'm willing to be one for the advancement of the health of mankind. I'm not talking about something completely foolish, but I understand people may be hurt.
I just don't want to do nothing.
I really, really like your line of thinking.
Posted on 5/20/14 at 10:09 pm to Hater Bait
There are certain protocols involving stem cells in which the actual editing of your genomic data isn't done in vivo.
If you weren't aware, we can essentially take any cell in the body and induce the formation of patient specific stem cells, which are known as inducible stem cells. This is done by exposing these cells to four specific transcription factors which effectively reprogram your cells to a pluripotent state.
Once induced, the cells can be transfected with a viral cassette containing the therapeutic gene. If the gene is installed at the correct genomic coordinate, they can then be allowed to differentiate in vitro before being transplanted back into the donor.
This protocol was used a few years ago to effectively cure mice afflicted with sickle cell anemia.
If you weren't aware, we can essentially take any cell in the body and induce the formation of patient specific stem cells, which are known as inducible stem cells. This is done by exposing these cells to four specific transcription factors which effectively reprogram your cells to a pluripotent state.
Once induced, the cells can be transfected with a viral cassette containing the therapeutic gene. If the gene is installed at the correct genomic coordinate, they can then be allowed to differentiate in vitro before being transplanted back into the donor.
This protocol was used a few years ago to effectively cure mice afflicted with sickle cell anemia.
This post was edited on 5/20/14 at 10:13 pm
Posted on 5/20/14 at 10:19 pm to Cs
quote:
There are certain protocols involving stem cells in which the actual editing of your genomic data isn't done in vivo. If you weren't aware, we can essentially take any cell in the body and induce the formation of patient specific stem cells, which are known as inducible stem cells. This is done by exposing these cells to four specific transcription factors which effectively reprogram your cells. Once induced, the cells can be transfected with a viral cassette containing the therapeutic genes. If the gene is installed at the correct genomic coordinate, they can then be allowed to differentiate in vitro before being transplanted back into the donor.
My body does not produce the Rs1 gene.
Retinoschisin is an extracellular protein that plays a crucial role in the cellular organization of the retina. This protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Monomeric retinoschisin contains 224 amino acids with a leader sequence that is cleaved off upon preparation in the cell for secretion.
Mutations in this gene are responsible for X-linked retinoschisis an early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision.
So, you're saying a virus can help my body "kick start" and produce this gene?
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