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re: Anyone in their 40s taking blood pressure meds?
Posted on 2/5/24 at 9:10 pm to tketaco
Posted on 2/5/24 at 9:10 pm to tketaco
quote:
zestoretic
Not a fan of doing a combo drug like this (lisinopril + hctz) instead of just using one medication and titration it up to figure out the minimal effective dose (I know there is some synergistic effect, but it’s harder to titrate up with the combo drugs. Is your Kidney function okay (recent Cr levels)? Honestly, I’m not a fan of HCTZ . Hypokalemia (low potassium), hyponatremia (low sodium), dehydration with subsequent orthostasis. Any other reason for the diuretic (edema in feet, Diastolic BP elevated out of proportion to systolic)? I think chlorthalidome is now recommended over HCTZ due to fewer side effects.
1
Posted on 2/5/24 at 9:18 pm to Ric Flair
quote:
I think chlorthalidome is now recommended over HCTZ due to fewer side effects.
Chlorthalidone gained popularity due to its inclusion in several important trials that are the basis for using thiazides at all (ALLHAT being one of the important ones). HCTZ gained popularity because it was on Wal Mart’s $4 list . Chlorthalidone tends to cause more hypokalemia and hyponatremia than HCTZ because it’s more potent, and the mechanism is literally to waste sodium and chloride in the proximal tubule.
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