re: Patients taking Eli Lilly's retatrutide lost 58 pounds, on average, in a phase 2 clinical

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Calories in < calories out

That's the key to weight loss. Bottom line

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Not necessarily. All calories do not interact with your body the same way. That's old school thought and not in touch with what is now known about certain forms of calories.

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Not in terms of weight loss, all else being equal. Eat a 1000 calories, burn 1100 and you lose some weight. But the fact is all else is rarely equal and usually reflected in your diet. What is left may be more lean muscle or more fat by percentage and that is related to where you get the calories from and what you are doing to burn calories.

The differences relate to how the body reacts to certain nutrients and food types as well as how energetic or sluggish you may feel. Some foods may actually rev up your metabolism and exercise, even something like a brisk walk, does rev up your metabolism for a period of time post-exercise.

And speaking as a fatty, there is only one way effective way to lose weight, and that is to be hungry for a while. You don't get fat by eating just the right amount of food, you won't lose it at any pace that feels like you are losing weight by simply exercising, and you will have to change your eating habits by limiting your calories.