re: How does Florida get rid of a plague of pythons?

It’s incredible the damage they’ve caused to the deer and other mammal populations. Something like a 95% decline in mammal populations.
As others have said there really isn’t any hope other than an unprecedented freeze, maybe. Or a lab developed virus that just targets the species (call Wuhan).

That area has exploded in population and plenty of numbskulls still release them when they get tired of having as a pet.