re: PRS Guitars

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None of this is absolute

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This is correct.

So much of an artist's tone is in his fingers. Also, amps and speakers play a HUGE part of tone. Most touring bands are playing at blistering levels which just isnt possible for bedroom playing.

As for an Amp, a Fender Princeton Reverb is about as good as it gets. The put your favorite pedals in front.

I'll say for my "72-74" Jerry Garcia rig, my set up is:
-Fender Strat with firebird pickups (so a bit hotter pickup than a regular single coil strat, but not a humbucker.)
-cheapo $30 Amazon pedal - Rowin Boost
-Analogman TS9 Tubescreamer
-Analogman Dual Delay
-Fender Princeton Reverb stock

This rig will get you 72-74 Jerry tones all day. I do not use the TS9 much, as the Rowin Boost pedal has a gain knob, and that after the firebird pickups somewhat do the same as Jerry's Strat o Blaster he had in his Alligator guitar.

** A big part of Jerry's tone and Dickie Betts in ABB's tone is the JBL speaker. No longer produced, but Weber speakers makes the California which is the same as the JBL.

Good luck!!