re: Should I even apply for jobs with companies that have more than 100 employees?

Yes.

My wife accepted a job last week at a company in B'ham with more than 100 employees and asked in the interview process if they would be implementing the mandate. They said no they would not be, many who work there are vaxxed and many aren't. If you want it, get it, if not no problem.

Her current company is a large insurance firm based in Chicago with offices in B'ham. They sent an email out right after Xiden's comments about the 100 employee mandate and that employees should be looking forward to the shot. She has had covid and is refusing the shot, same as me.