Three candidates immediately come to mind:
(1) The 2003 NCG. That Oklahoma squad was an offensive juggernaut during the regular season. They scored 65 on #11 Texas, 34 on #24 Missouri, 52 on #14 Oklahoma State (Miles coincidentally), and for good measure dropped 77 on hapless TAMU. The LSU defense held them to 14 and actually scored the game winning TD on Spears' INT;
(2) 2003 UGA regular season/SECCG - Well documented;
(3) LSU-VT 2007 - The LSU defense brutalized and suffocated the offense of a team which would win the ACC, appear in the Orange Bowl, and finish ranked in the top five nationally.
EDIT: 2011 regular season against Bama deserves consideration as well. The defense and special teams single-handedly won that game. Had we not embarassed ourselves in New Orleans, Reid's INT would probably live in legend as the greatest individual defensive effort in LSU history.
This post was edited on 5/8 at 12:53 pm