Ryan just needs to do exactly what Romney did. Speak to his strengths, call out Biden's BS, and stay classy/likable.
Let Biden spout the typical democrat BS of raising taxes on the rich and "investing" (more spending) in the virtuous aspects of the government like education and infrastructure.
Biden can make the same boring talking points interesting, but if he tries and gets too cute, he may make a major gaffe.
Ryan should focus on the positive aspects of himself/Romney and their plans and only respond to inaccuracy and slander.