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SSRI/SNRI med question?

Posted on 12/15/16 at 8:01 pm
Posted by RandySavage
Member since May 2012
30842 posts
Posted on 12/15/16 at 8:01 pm
I read the thread yesterday about getting off them and it seemed like several people had experience with these drugs.

Long story short... about three months ago, after a terrible experience with Lexapro I started Cymbalta. After a couple of weeks everything was great and I was my normal self again. Last 2 1/2 months have been the same. All the sudden yesterday I woke up feeling kind of weird and now today it's like I'm full on back in anxiety/depressed mode.

Is it normal for these things to just stop working instantly like that or is there any chance it could just be like a couple of days funk? I'm trying not to freak out that I'm going to plunge back into the place I was when I started them but it's hard when those feelings start creeping back in.

Any help?
Posted by 3deadtrolls
lafayette
Member since Jan 2014
5703 posts
Posted on 12/15/16 at 8:05 pm to
Have you tried snapping into a Slim Jim?
Posted by LSU Wayne
Walker
Member since Apr 2005
4365 posts
Posted on 12/15/16 at 8:09 pm to
Any other recent med additions/changes?
Posted by Stiffy
Baton Rouge
Member since Oct 2014
460 posts
Posted on 12/15/16 at 8:10 pm to
Read the Package Insert on Cymbalta. Not that great of if an anti-depressant. If you are drinking alcohol with it, the depression is actually increased.
So, the answer to your question isn't so simple. Anyone who answers in definite terms doesn't have the experience to do so.
Not being a jerk, just trying to help.
Posted by RandySavage
Member since May 2012
30842 posts
Posted on 12/15/16 at 8:12 pm to
I don't drink and have not changed anything else.

I haven't gotten much sleep this week so I'm praying that I'm just really tired and misreading my feelings.
Posted by Jake88
Member since Apr 2005
68235 posts
Posted on 12/15/16 at 8:13 pm to
quote:

it could just be like a couple of days funk
Posted by PillPusher
Gulf Coast
Member since Oct 2009
5711 posts
Posted on 12/15/16 at 8:14 pm to
Anti depressants can actually cause new or worsening depression. So there's that.
Posted by EastTxTiger
Dry Desert
Member since Feb 2007
570 posts
Posted on 12/15/16 at 8:16 pm to
quote:

It could just be like a couple of days funk


This

I take 3 diff SSRI's and the funk still happens.
Posted by AUCE05
Member since Dec 2009
42567 posts
Posted on 12/15/16 at 8:18 pm to
Could need your meds adjusted.
Posted by LEASTBAY
Member since Aug 2007
14290 posts
Posted on 12/15/16 at 8:23 pm to
Look into Effexor.
Posted by DosManos
Member since Oct 2013
3552 posts
Posted on 12/15/16 at 8:24 pm to
Be very careful with Cymbalta. In fact, get off of it. It's very difficult to withdraw from. It's short half-life combined with the fact that the smallest dose is 20mg means it's incredibly hard to wean yourself off of.

I wonder what your terrible experience was with Lexapro and why your doctor thinks Cymbalta would be different. I have strong feelings about this topic and, while I want to tell you to run away from this shite, I don't want to interfere with your medical care as I don't know you.
Posted by DosManos
Member since Oct 2013
3552 posts
Posted on 12/15/16 at 8:26 pm to
quote:

All the sudden yesterday I woke up feeling kind of weird and now today it's like I'm full on back in anxiety/depressed mode.


Be happy that you have this awareness. These drugs, for certain people, can blunt self-awareness and leave one spellbound.
Posted by tigerjjs
Baton Rouge
Member since Sep 2006
1238 posts
Posted on 12/15/16 at 8:32 pm to
Dude, call your doctor.
Posted by Stiffy
Baton Rouge
Member since Oct 2014
460 posts
Posted on 12/15/16 at 8:34 pm to
This is exactly what I meant to say but better said.
You are now blocking the re-uptake of norepinephrine. This is a very strong neuro transmitter. Don't take advise from someone who doesn't have a M. D. Shindig their name.
Posted by Roger Klarvin
DFW
Member since Nov 2012
46511 posts
Posted on 12/15/16 at 8:39 pm to
Cymbalta isn't a great antidepressant, I've had better results prescribing Effexor. Remeron is actually the best combination of benefits and minimal side effects in my experience but it does increase appetite a lot.

I'd be interested in hearing about your experience with Lexapro as it's generally considered the "best" of the SSRIs.
Posted by SundayFunday
Member since Sep 2011
9299 posts
Posted on 12/15/16 at 8:54 pm to
Yeah, call your doctor. It could be a number of things but if the anxiety is as serious as you say its not something you care to prolong.

What happened with Lexapro? Normally ive heard thats a real good one but obviously its different with everyone.
This post was edited on 12/15/16 at 8:56 pm
Posted by wfallstiger
Wichita Falls, Texas
Member since Jun 2006
11431 posts
Posted on 12/15/16 at 9:05 pm to
Call your physician, now.

Just recently discontinued Lexapro. Didn't believe the benefits to significantly outweigh undesired effects (physical)...helped with depression/anxiety, though.

Recently began, last week, Wellbutrin...too early to tell
Posted by TerryDawg03
The Deep South
Member since Dec 2012
15714 posts
Posted on 12/15/16 at 9:17 pm to
quote:

Dude, call your doctor.
Posted by LSUSkip
Central, LA
Member since Jul 2012
17552 posts
Posted on 12/15/16 at 9:38 pm to
First off, you will be fine. Take a deep breath. Secondly, it could very well be short term, as anyone with anxiety/depression will tell you, you will have days no matter what. I'm in the same boat, today and yesterday. Keeping it quiet though, trying to make it as smooth as possible, but my wife has noticed.Third, call your Dr.ASAP, probably not an emergency, but you shoukd make that call. Fourth, If you can sleep, sleep. Always helps me, i slept for four hours when i got home today.
Posted by martiallaw
Louisiana
Member since Jan 2008
1454 posts
Posted on 12/15/16 at 9:39 pm to
Have you done any genetic testing? You are probably a CYP2C19 poor metabolizer and/or a SLC6A4 Short/Short or Long/Short if you went from a SSRI to a SNRI and had better results.
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