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Biology, Chemist and Biochemist OTers: Help me understand weight loss.

Posted on 4/3/17 at 7:54 am
Posted by MontyFranklyn
T-Town
Member since Jan 2012
23830 posts
Posted on 4/3/17 at 7:54 am
I was watching a video on Ketosis. The guy was explaining it using alot of biochemistry jargon, but I still was able to interpret it in my own way.

I deduced that your body runs of a primary fuel and a back up fuel. Glucose is the primary fuel. Glucose is produced in your body from carbs and sugar. If the "tank" for glucose fuel fills, due to you not burning it, the excess glucose is then stored into fat cells. Your body will only burn these fat reserves when the glucose "tank" is empty.

I know it is alot more complex than that, but is this a good and simple way of understanding a complex biochemical process?
Posted by tigerstripedjacket
This side of the wall
Member since Sep 2011
3001 posts
Posted on 4/3/17 at 7:55 am to
Do you even lift, bro?
Posted by AUCE05
Member since Dec 2009
42568 posts
Posted on 4/3/17 at 7:55 am to
That's how I understand it. Some say it is how our body should operate.

ETA:

Also, sugar is processed by the liver, and enters the blood stream causing spikes in blood sugar. That also causes blood vessels to inflame, which can lead to blockages.
This post was edited on 4/3/17 at 7:58 am
Posted by jack6294
Greater Baton Rouge Area
Member since Jan 2007
4033 posts
Posted on 4/3/17 at 7:56 am to
Yes

Read "Protein Power"

Goes into it deeper
Posted by Hangover Haven
Metry
Member since Oct 2013
26610 posts
Posted on 4/3/17 at 8:02 am to
Move more, eat less....
Posted by Ingeniero
Baton Rouge
Member since Dec 2013
18287 posts
Posted on 4/3/17 at 8:02 am to
Calories in, calories out baw
Posted by shotcaller1
Member since Oct 2014
7501 posts
Posted on 4/3/17 at 8:03 am to
Consume less calories than you burn
Posted by KG6
Member since Aug 2009
10920 posts
Posted on 4/3/17 at 8:08 am to
My understanding isn't necessarily that you will burn glucose first. It is just an "easier" source of fuel. It can be broken down into energy more quickly. Therefore, at higher rates of physical exertion, you will burn glucose energy stores. When you run low, you get that bonked/drained feeling and you have no more fuel in the tank (fat can't break down fast enough to supply the energy). At lower rates of energy exertion, your body can run on fat energy stores. It's all about your heart rate and metabolic zone.

This is where people see that "fat burning zone" on the treadmill and think they need to work out in that zone to burn their fat. That's not necessarily a truthful idea. You don't lose weight 'better' just because you burned fat in that zone. You are just utilizing that as a source of energy at that level of physical exertion. In the end, you burned X amount of calories. If you burned X amount of calories in the "glucose burning zone" you'd have done the same amount of good in terms of weight loss. The source of energy just becomes more important in endurance sports like running a marathon or something.

I don't claim to be an expert. My input is about as good as any other bro-science out there. Just from a different perspective when researching running/triathlon nutrition.
This post was edited on 4/3/17 at 8:17 am
Posted by SCndaBR
BR
Member since Dec 2015
517 posts
Posted on 4/3/17 at 8:15 am to
Yes. That is the simplest way to put it. This is why it is best to workout in the morning. Your fuel reserves or glucose are at your lowest. You will burn more fat faster in the AM.
Posted by TIGERBAIT2020
The Red Zone
Member since Aug 2004
802 posts
Posted on 4/3/17 at 8:20 am to
Wanna lose wt?
I have a foolproof 2-step weight loss program.

Step #1 - Eat Less.

Step #2 - Move around more.

Posted by Libertariantiger
Member since Nov 2012
981 posts
Posted on 4/3/17 at 8:21 am to
I'm none of those in the title, but my company just did a 17 person fat loss diet challenge. We had 8 people who did very well. We all were calipered by the same person beginning and end. Went for two months.
There was a few interesting things.
The top performers all lost roughly the same amount of body fat but different amounts of weight. We all lost between 1# and 1.5# of fat per week.
The two winners did not starve themselves. They both were the only ones to plan and measure their food out. The person who lost the most weight was visibly thinner, but lost less fat.
Many did different diets and had similar success. Do not drop your calories too low. Eat and exercise. Cut sugar and try to loose 1.5 pounds a week after week one. Week one would be a little more.
The winners both lost 12# compared to the top loss at 28# over two months. Winners were able to lift weights, do some cardio, and they timed their meals.
Posted by Pecker
Rocky Top
Member since May 2015
16674 posts
Posted on 4/3/17 at 8:22 am to
Basically your body is going to burn carbs unless there are no carbs. Then it will start burning your fat stores.

So if you limit your carbs you'll be able to lose weight faster. If you eat a pizza and then go to the gym and run 6 miles, you're just going to be burning off the carbs from the pizza, not fat stores.

It's a little more complicated than that, but if you use that as a general guide, you'll lose fat a lot faster.
This post was edited on 4/3/17 at 8:25 am
Posted by Junky
Louisiana
Member since Oct 2005
8381 posts
Posted on 4/3/17 at 8:28 am to
quote:

My understanding isn't necessarily that you will burn glucose first. It is just an "easier" source of fuel. It can be broken down into energy more quickly. Therefore, at higher rates of physical exertion, you will burn glucose energy stores. When you run low, you get that bonked/drained feeling and you have no more fuel in the tank (fat can't break down fast enough to supply the energy). At lower rates of energy exertion, your body can run on fat energy stores. It's all about your heart rate and metabolic zone.

This is where people see that "fat burning zone" on the treadmill and think they need to work out in that zone to burn their fat. That's not necessarily a truthful idea. You don't lose weight 'better' just because you burned fat in that zone. You are just utilizing that as a source of energy at that level of physical exertion. In the end, you burned X amount of calories. If you burned X amount of calories in the "glucose burning zone" you'd have done the same amount of good in terms of weight loss. The source of energy just becomes more important in endurance sports like running a marathon or something.

I don't claim to be an expert. My input is about as good as any other bro-science out there. Just from a different perspective when researching running/triathlon nutrition.


Pretty much this. Ketosis isn't going to help you lose weight faster, it is a state of fuel burning for the body. Most people burn glucose because we constantly dump excess sugar/complex carbs into our system and we do not give our bodies a chance to rid ourselves of it.

Think of it as stages of fuel - The body prefers burning fat but must rid itself of other, maybe harmful, fuels first. The body burns ethanol off first and foremost as it can be poisonous. Then switches to glucose until it is in safe levels in the bloodstream. Once glucose levels are safe, it will switch and run off fat.

We carry fat around on our bodies as a storage tank for fuel in case of emergencies. It is much easier and efficient to carry around that much energy in fat than any other substance. Protein is extremely taxing on the body to break down. Gluconeogenesis is a demand driven pathway that wont start unless it absolutely needs to - it is not supply driven. Hormones are very important to have corrected because they will determine fat storage. Basically, if your body doesn't recognize the fat on you, it wants to store more.
Posted by oleyeller
Vols, Bitch
Member since Oct 2012
32021 posts
Posted on 4/3/17 at 8:32 am to
it isn't rocket science. Eat less, move more. Lose weight every time
Posted by TigerTatorTots
The Safeshore
Member since Jul 2009
80781 posts
Posted on 4/3/17 at 8:39 am to
quote:


Wanna lose wt?
I have a foolproof 2-step weight loss program.

Step #1 - Eat Less.

Step #2 - Move around more.
Check out the documentary called Fed Up on Netflix. 1.5 hours and eye opening regarding your theory
Posted by shutterspeed
MS Gulf Coast
Member since May 2007
63344 posts
Posted on 4/3/17 at 8:39 am to
quote:

it isn't rocket science. Eat less, move more. Lose weight every time


While there is truth to that, if you could optimize weight loss, then why wouldn't you?

Ketosis supercharges weight loss.
Posted by David Crockett
Member since Apr 2017
91 posts
Posted on 4/3/17 at 8:41 am to
Posted by Rebel
Graceland
Member since Jan 2005
131396 posts
Posted on 4/3/17 at 8:45 am to
That is exactly how I understand it. That is why high protein low carb diets are so effective.
Posted by Bmath
LA
Member since Aug 2010
18670 posts
Posted on 4/3/17 at 8:49 am to
quote:

This is where people see that "fat burning zone" on the treadmill and think they need to work out in that zone to burn their fat. That's not necessarily a truthful idea. You don't lose weight 'better' just because you burned fat in that zone.


A lot of this is actually related to cortisol production. Cortisol is a stress hormone that gets released with certain levels of exertion, and can lead to fat retention.

It's why a 60 minute walk may have more fat loss benefits than a 30 minute run.

The run is stressful on the body and triggers cortisol production while a moderate walk never hits that zone.

ETA: For the ignorant down voter that is too dumb to even formulate a response. This is one of the main reasons that calories in < calories out fails after a couple of months for people needing to lose large amounts of weight. Our bodies are really good at not starving and losing weight. This is one of the ways it adapts.
This post was edited on 4/3/17 at 9:04 am
Posted by zatetic
Member since Nov 2015
5677 posts
Posted on 4/3/17 at 9:09 am to
Ketosis (which is a high fat diet) uses fat as energy. All the other diets uses glucose as energy.

So if you are on a diet to lose weight ketosis is best. It keeps your hormones in great shape, because hormones are from fat and you won't lose muscle because muscle cannot break down into ketones but it can break down into glucose. Fatty food is hard to break down and burns quite a bit of energy trying to process it. It is why if you eat a fatty food you will feel warmer because your expending energy trying to digest it. Les Stroud even pointed out eating straight fat right before sleeping is great help to keep warm when he was survivormanning it up in some cold area. Ketosis gives the benefits of fasting while still eating. It theoretically may be impossible to get cancer while in ketosis since you will have no glucose for the cancer to use (this is a big leap of faith but it is known to help treat cancer). What I've read says no one can get approval to do an actual study with human subjects on whether a ketosis diet can treat cancer.

In all the other diets fat is typically the last thing to lose because it is the hardest thing to breakdown into glucose. Sugar is inflammatory for your whole body. Cancer runs on glucose. Literally almost everything bad healthwise comes from sugar and grains. If you aren't using the energy immediately it turns into fat because it takes no energy to breakdown sugar and grains.
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