As others are saying, it's not so much his doping (everyone at the front of the peloton certainly did, so it was an even playing field), and it wasn't the decade+ of denials. It was his concerted efforts to destroy anyone who told the truth: Betsy and Frankie Andreu, Emma O'Reilly (Postal Service team masseuse), Floyd Landis, Tyler Hamilton, multiple reporters, etc. And when Greg LeMond gave his expert opinion (having recovered from a devasting injury that kept him away from cycling for two years) that it was impossible for Lance to have gone from deathbed to TdF champ in 2.5 years, he was destroyed too. I believe Lance turned Trek against LeMond. At the time, Trek manufactured LeMond bikes, but I think they broke the contract and dropped him.
I saw Lance take shots on Twitter at Juliet Macur, a pretty dispassionate reporter for the NYT, simply for reporting the news—she never took shots at him, but she was clearly not a "friend of Lance," so he took shots at her. Last year I took a screen shot of his Twitter because he was being his true self for a moment, and I knew he would delete this tweet pretty quickly.
Lance is just a nasty, nasty dude who owes a lot of people apologies with a sincerity that you know he won't be able to muster. I'm surprised he's gonna admit doping because it seems like he would still be vulnerable to prosecution for taking public money (US Postal Service) for fradulent purposes, and I think there were also conspiracy charges.