Is zyn really that bad for you?

I used them to quit smoking after 30 years. I figure it’s got to be better for me than that.

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Holy crap I missed that buzz.

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Same. I've been off nicotine for 4 years probably. Scared to try them. It's great there are safer alternatives to dip and cigarettes now though.

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Even the 3's are good for me right now. But this time next month I'll be slamming 6's all day if I'm not careful

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I quit dipping 2 or 3 years ago and have been on Zyn ever since. It doesn't deteriorate your gum line like tobacco, and I honestly can't find any sources indicating it's any worse for you than something like caffeine.

I was trying to quit Zyn recently and I was able to stop for 2 days. I didn't have any withdrawal headaches, nausea or anything. Just had the craving for it. Can't really explain why but I enjoy them. I was quitting more because I was going through a lot. Think I spent $200 a month on them. I'm still on them, but I just scaled way back on how often I throw one in. Now I'm going through a can about every two days.

On the health side, I'm convinced they're nothing burgers.

If you're wanting to save some money on them, go to nicokick dot com and they're half the price of what you get them for in the convenience store.

What is Zyn? Is it like snus?

Nicotine has health benefits. I haven’t studied the optimal dosage and how it compares to typical zyn usage.

Article - Molecular Medicine Reports

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Nicotine administration can improve cognitive impairment in Alzheimer's disease (AD), and dyskinesia and memory impairment in Parkinson's disease (PD). In terms of its mechanism of action, nicotine slows the progression of PD by inhibiting Sirtuin 6, a stress-responsive protein deacetylase, thereby decreasing neuronal apoptosis and improving neuronal survival. In AD, nicotine improves cognitive impairment by enhancing protein kinase B (also referred to as Akt) activity and stimulating phosphoinositide 3-kinase/Akt signaling, which regulates learning and memory processes. Nicotine may also activate thyroid receptor signaling pathways to improve memory impairment caused by hypothyroidism. In healthy individuals, nicotine improves memory impairment caused by sleep deprivation by enhancing the phosphorylation of calmodulin-dependent protein kinase II, an essential regulator of cell proliferation and synaptic plasticity. Furthermore, nicotine may improve memory function through its effect on chromatin modification via the inhibition of histone deacetylases, which causes transcriptional changes in memory-related genes. Finally, nicotine administration has been demonstrated to rescue long-term potentiation in individuals with sleep deprivation, AD, chronic stress and hypothyroidism, primarily by desensitizing a7 nicotinic acetylcholine receptors. To conclude, nicotine has several cognitive benefits in healthy individuals, as well as in those with cognitive dysfunction associated with various diseases. However, further research is required to shed light on the effect of acute and chronic nicotine treatment on memory function.

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