Road Trip to Colorado from Louisiana

Hello.

My wife and I would like to start planning a road trip for our one year anniversary in late November, specifically Thanksgiving weekend. We are still not sure if it's possible yet (mainly due to unknown weather conditions) but I figured it wouldn't hurt to plan something ahead of time to see if it's feasible or not. I know Colorado is a favorite among many travelers, so I am hoping to receive some good feedback here. Neither of us have visited Colorado but have always wanted to go. Here are some details of what we would like to do...

Visit a bed and breakfast type place for 2-3 nights and mostly just relax in a smaller town. This would be our first time to Colorado for the both of us so we don't want to do too much, mainly trying to avoid the big cities/tourist areas like Denver, Aspen, Breckenridge, etc. I found a great deal for a bed and breakfast called Black Bear Manor in Ouray, SW CO. Seems like the perfect small community for us right in the middle of the mountains. We would like to do a little sightseeing while there, maybe some hiking and beginner-type skiiing (we have never skied before but would love to) obviously all of this is dependent on the weather conditions. Which leads me to my next paragraph...

What are the average temps like for western CO in late November? What is the average snowfall for this time of year? Should we be expecting heavy snow while driving into northern NM and into CO (obviously my main concern being from LA)? We have never driven in snow so it kind of freaks me out a little. Here is a tentative plan/route we are going to be taking...

Traveling from Lake Charles: 171 north, west on I20 through Dallas, Abilene, Lubbock, and then hit I40 through Albuquerque and then north on 550 into CO and looks like straight into Ouray (according to Google maps). This route would avoid any tolls, and would take about 20 hours (not counting traffic, weather conditions, stops, etc.) We will more than likely cut that in half and stay somewhere about midway through the drive. Right now we'd be looking at leaving on Wednesday 11/22, stay 3 nights at the bnb, and head back on Sunday 11/26. I know that weekend might be the worst possible weekend to travel but there are a few reasons behind choosing that weekend... We are both off from work for the holidays (would give us extra days to enjoy Colorado) and our one year anniversary is 11/26.

Is this drive even doable in two days? Am I getting way ahead of myself here? Any tips/advice would be greatly appreciated!! Thanks in advance.