It will come eventually but not yet.
A likely scenario will be a complete economic crash necessitating that the federal government take control of the means of food production.
What does that mean? That means that food would be grown in places like Arkansas and Louisiana and shipped to places like New York City which has a population about the size of Louisiana and Arkansas combined while people in places like Arkansas and Louisiana largely starved or had to lose everything and move to camps where they could get fed.
Now ask the question about secession in that sort of scenario. Would the people of places like Arkansas and Louisiana sit back and allow food and other resources produced in their states to be sent elsewhere without a fight?
Secession is unrealistic as long as being the United States offers more benefits than drawbacks. But when the negatives outweigh the positives and those in the hinterlands are treated more like subjegated peoples than citizens, the US will break apart as surely as Rome did and for the same reasons.
This post was edited on 11/13 at 2:17 pm