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Wow. Brazil Study Shows *early* HCQ significantly decreases hospitalization rates

Posted on 4/17/20 at 3:18 pm
Posted by OKtiger
Tulsa, OK
Member since Nov 2014
8595 posts
Posted on 4/17/20 at 3:18 pm
(n=636) with a p<0.001; 412 received HCQ/Azithromycin and the control group 224 did not receive medication.

Hospitalization Rate in HCQ/Z pack Group: 1.9%
Hospitalization Rate in Control: 5.4%

Those who were treated in the first 7 days of symptoms: 1.17%
Those who were treated in the after the first 7 days of symptoms: 3.2%

Link to Preprint

Posted by dandyjohn
Member since Apr 2009
804 posts
Posted on 4/17/20 at 3:31 pm to
yep, brazil and india is where i want to get my cutting edge healthcare from.
Posted by LNCHBOX
70448
Member since Jun 2009
84118 posts
Posted on 4/17/20 at 3:31 pm to
quote:

yep, brazil and india is where i want to get my cutting edge healthcare from.




Other countries have found the same.
Posted by blueridgeTiger
Granbury, TX
Member since Jun 2004
20277 posts
Posted on 4/17/20 at 3:34 pm to
Of course you must disbelieve this - if Trump says it "shows promise" it must be bad.
Posted by kywildcatfanone
Wildcat Country!
Member since Oct 2012
119181 posts
Posted on 4/17/20 at 3:35 pm to
Instead of money, we need to send this to everyone.
Posted by AUsteriskPride
Albuquerque, NM
Member since Feb 2011
18385 posts
Posted on 4/17/20 at 3:35 pm to
quote:

yep, brazil and india is where i want to get my cutting edge healthcare from


Cutting edge, using medications off label..
Posted by Tiguar
Montana
Member since Mar 2012
33131 posts
Posted on 4/17/20 at 3:36 pm to
this is actually a pretty big deal if valid

closest thing we have to a real trial since this shite started and they found a statistical difference and even gave us a NNT.
Posted by xxTIMMYxx
Member since Aug 2019
17562 posts
Posted on 4/17/20 at 3:36 pm to
quote:

yep, brazil and india is where i want to get my cutting edge healthcare from.


I know that one of the leading hospitals in the country is using it as first recommendation (5 days), so there has to be something to it.
This post was edited on 4/17/20 at 3:37 pm
Posted by xxTIMMYxx
Member since Aug 2019
17562 posts
Posted on 4/17/20 at 3:37 pm to
There are ongoing clinical trials.
Posted by Methuselah
On da Riva
Member since Jan 2005
23350 posts
Posted on 4/17/20 at 3:37 pm to
Excellent news if true.
Posted by Scruffy
Kansas City
Member since Jul 2011
72120 posts
Posted on 4/17/20 at 3:41 pm to
quote:

Of course you must disbelieve this - if Trump says it "shows promise" it must be bad.

Well, the downvotes show that some people hold that view.

Rather people die than have Trump proven correct.
Posted by OKtiger
Tulsa, OK
Member since Nov 2014
8595 posts
Posted on 4/17/20 at 3:41 pm to
quote:

yep, brazil and india is where i want to get my cutting edge healthcare from.


I think it's ironic because there was a Brazil trial that everyone was referencing a couple days ago showing HCQ's "ineffectiveness and safety hazards" when the scientists were giving 1200 mg doses to patients who were effectively on their death bed.

Everyone wanted to believe that trial
Posted by cwil177
Baton Rouge
Member since Jun 2011
28432 posts
Posted on 4/17/20 at 3:42 pm to
Hydroxychloroquine fails first meaningful RCT - PulmCrit
quote:

- This is the first multi-center RCT investigating the use of hydroxychloroquine for COVID-19. 150 adult patients hospitalized with COVID-19 were randomized in an open-label, non-blinded fashion.

- Hydroxychloroquine had no effect on the duration of viral detection (despite the use of high doses and a prolonged 2-3 week course).

- Clinically, there was no discernible beneficial effect from hydroxychloroquine. However, hydroxychloroquine did appear to cause some side-effects (most notably diarrhea).

- Further studies on hydroxychloroquine will likely be emerging soon. For now, the best available evidence does not support the use of hydroxychloroquine in COVID-19.

- Given evidence of harm without evidence of benefit, it seems prudent to restrict the use of hydroxychloroquine to randomized controlled studies for the time being.
Posted by TigerstuckinMS
Member since Nov 2005
33687 posts
Posted on 4/17/20 at 3:43 pm to
quote:

yep, brazil and india is where i want to get my cutting edge healthcare from.

Countries like those tend to have the most experience with lethal communicable diseases due to their tropical nature, lower standard of living, and high numbers of the poor living in tight quarters.
Posted by HogBalls
Member since Nov 2014
8591 posts
Posted on 4/17/20 at 3:43 pm to
Posted by LNCHBOX
70448
Member since Jun 2009
84118 posts
Posted on 4/17/20 at 3:44 pm to
quote:

Hydroxychloroquine fails first meaningful RCT - PulmCrit
quote:

Treatment was initiated late, an average of 16-17 days after disease onset:


Libs furiously downvoting anything that might be positive
This post was edited on 4/17/20 at 3:46 pm
Posted by cwil177
Baton Rouge
Member since Jun 2011
28432 posts
Posted on 4/17/20 at 3:44 pm to
Also, this is a study on patients who never got a COVID test
Posted by jeffsdad
Member since Mar 2007
21424 posts
Posted on 4/17/20 at 3:45 pm to
HCQ should have been given anybody and everybody the first day of symptoms at the first onset of this crap. And masks should have been mandated as soon as it became known to be in the USA. These 2 things would have held back this crap and it would be totally done much quicker than it will be now.

Of course, Democrats would have screamed because there would not be a crisis now.
Posted by Tiguar
Montana
Member since Mar 2012
33131 posts
Posted on 4/17/20 at 3:45 pm to
on going doesnt help me much RIGHT NOW.
Posted by cwil177
Baton Rouge
Member since Jun 2011
28432 posts
Posted on 4/17/20 at 3:48 pm to
quote:

Treatment was initiated late, an average of 16-17 days after disease onset:

Definitely a valid criticism! Still the best data we have so far.
quote:

Adverse events were found in 30% of patients treated with hydroxychloroquine, versus 9% of the control group. Although not statistically significant, progression to severe disease occurred at a higher rate in patients receiving hydroxychloroquine.

We know there are harms, though.
quote:

Of course, it is possible that earlier use of hydroxychloroquine could be beneficial (e.g., perhaps at the first signs of illness on an out-patient basis). This is under investigation and additional data is likely to be forthcoming soon. Even if this does work in the outpatient clinic, it would probably have little impact on the management of these patients within the intensive care unit.

I would love to see a double blind, placebo controlled RCT on early administration of HCQ + zinc in patients getting hospitalized. I think this actually holds promise.
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