re: Key West- Pier House Resort & Spa

Casa Marina is prolly a nicer hotel than the Pier House. The PH is on Duval closer to Mallory Sq and Casa is on the other side of the island. It's a bit further away from most of the action (i.e. Duval st)
Lattitudes does require taking the hotel ferry to get there. Nice view, people like the experience. The food is mostly a heat and serve operation, soup out of bag and what not. Nothing is really made over there but the presentation isn't bad. Best bet is to call for reservations, they block the books online because they lose a lot of seating in bad weather. For dinner there are much better options.