re: Building a home pre-wired for 5.1

Your center channel needs to be directly above or below your TV. Your two fronts need to be on the TV left and right. Your two surround speakers can be either left and right behind your listening position or directly left and right of your listening position. Sub placement is not as important. Just put it where it sounds best.
As previously mentioned, I don't see how the setup you diagram would produce anything worthwhile.