re: Creutzfeldt-Jakob disease **updated pg 5

That fat stupid frick looks like a tick about to rupture.

For those worried about venison, there is good evidence that there is a strong species barrier between cervid CWD and humans.

LINK

"In vitro and in vivo models have also been developed to test the strength of the cervid CWD to human transmission barrier. In vitro studies have demonstrated that a strong barrier exists, but it has not been absolute in all studies [7]. In vivo studies have used non-human primate models and transgenic mice to assess the CWD species barrier. Squirrel monkeys were susceptible to CWD but cynomolgus macaques were not [8,9,10,11]. Macaques are a closer genetic match to humans overall and have traditionally been susceptible to most human-tropic prion diseases, so the observation that macaques are resistant to CWD infection is encouraging."


The above study used "humanized mice" (tg66) that can produce human prion proteins and are susceptible to Creutzfeldt-Jakob disease. They loaded up these mice with CWD prions, but did not find evidence for CWD transmission

"In conclusion, our current study confirmed that even on second passage, CWD-inoculated, humanized mice did not develop prion disease."

"tg66 mice in our experiments appear to be a dead-end host for CWD transmission."

"The failure of CWD to adapt to a human tropic prion agent after two serial passages in tg66 mice indicates a strong species barrier inhibits CWD prion conversion of human prion proteins."

This strong species barrier explains why Americans eat three hundred million pounds of venison per year and yet not a single case of CWD to humans has been found.

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I find it interesting that people get freaked out over an obscure ,rare disease such as CJD

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Well apparently not that rare judging from this thread

Doctors saying it’s spontaneous just means they have no fricking clue but what is telling to me is all you coonasses ITT having so many instances with this rare disease and you all eat squirrel brains like it’s the Great Depression.

Well I’m 72,if avg of 300 people die from it yearly,21,600 people have died from it during my lifetime.I’ve only known 1 person,my cousin that died first of this year.
I worked 31 years full time ICU,I only saw 1 case in all those years so it’s pretty rare.
Pt. I saw had it as a suspected diagnosis,confirmed by autopsy.
I doubt my cousin ever ate squirrel brains,her dad was a fisherman,never hunted.
I seriously doubt squirrels have anything but a miniscule chance of acquiring CJD,they aren’t congregant feeders like cows,sheep and deer.

As I said in an earlier post,the head was my favorite part of the squirrel,the cheek meat was the best of the squirrel and the brains are just good.It’s just what one gets used to.I know people that have eaten rattlesnakes and say they’re good but I could never bring myself to eat a snake.
I don’t know if brains are particularly nutritious but organs are the most nutritious part of a animal.The American Indians instinctively knew that and prized the organs,all the stuff we throw away or feed to the dogs they ate.

My uncle passed from it some years back. I have discussed it and CJD multiple times on here and the OB as it relates to CWD.