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re: Creutzfeldt-Jakob disease **updated pg 5
Posted on 11/21/23 at 7:20 pm to DeltaHog
Posted on 11/21/23 at 7:20 pm to DeltaHog
quote:
I’m shocked how many people eat squirrel brains. What the hell folks
This was my exact thought. We have the greatest standard of living in the history of the world and people are out there eating goddam squirrel brains. Ain’t nobody that poor. That’s a choice.
Posted on 11/21/23 at 7:42 pm to JoseVargasTX
Same for MIL husband, process of elimination after running every test and consulting with larger hospitals.
Posted on 11/21/23 at 7:46 pm to Sao
That fat stupid frick looks like a tick about to rupture.
Posted on 11/21/23 at 7:46 pm to LSUA 75
quote:
But there are those that won’t eat deer and are horrified at the idea of eating squirrel heads(my favorite part,BTW) from the speculative risk of catching CJD,which has never been proven and is very rare.
I have a cousin that died last year from it,Drs said it was spontaneous which I have no idea how that is determined vs.acquired.
Did your cousin also eat squirrel heads?
Posted on 11/21/23 at 8:10 pm to JoseVargasTX
For those worried about venison, there is good evidence that there is a strong species barrier between cervid CWD and humans.
LINK
"In vitro and in vivo models have also been developed to test the strength of the cervid CWD to human transmission barrier. In vitro studies have demonstrated that a strong barrier exists, but it has not been absolute in all studies [7]. In vivo studies have used non-human primate models and transgenic mice to assess the CWD species barrier. Squirrel monkeys were susceptible to CWD but cynomolgus macaques were not [8,9,10,11]. Macaques are a closer genetic match to humans overall and have traditionally been susceptible to most human-tropic prion diseases, so the observation that macaques are resistant to CWD infection is encouraging."
The above study used "humanized mice" (tg66) that can produce human prion proteins and are susceptible to Creutzfeldt-Jakob disease. They loaded up these mice with CWD prions, but did not find evidence for CWD transmission
"In conclusion, our current study confirmed that even on second passage, CWD-inoculated, humanized mice did not develop prion disease."
"tg66 mice in our experiments appear to be a dead-end host for CWD transmission."
"The failure of CWD to adapt to a human tropic prion agent after two serial passages in tg66 mice indicates a strong species barrier inhibits CWD prion conversion of human prion proteins."
This strong species barrier explains why Americans eat three hundred million pounds of venison per year and yet not a single case of CWD to humans has been found.
LINK
"In vitro and in vivo models have also been developed to test the strength of the cervid CWD to human transmission barrier. In vitro studies have demonstrated that a strong barrier exists, but it has not been absolute in all studies [7]. In vivo studies have used non-human primate models and transgenic mice to assess the CWD species barrier. Squirrel monkeys were susceptible to CWD but cynomolgus macaques were not [8,9,10,11]. Macaques are a closer genetic match to humans overall and have traditionally been susceptible to most human-tropic prion diseases, so the observation that macaques are resistant to CWD infection is encouraging."
The above study used "humanized mice" (tg66) that can produce human prion proteins and are susceptible to Creutzfeldt-Jakob disease. They loaded up these mice with CWD prions, but did not find evidence for CWD transmission
"In conclusion, our current study confirmed that even on second passage, CWD-inoculated, humanized mice did not develop prion disease."
"tg66 mice in our experiments appear to be a dead-end host for CWD transmission."
"The failure of CWD to adapt to a human tropic prion agent after two serial passages in tg66 mice indicates a strong species barrier inhibits CWD prion conversion of human prion proteins."
This strong species barrier explains why Americans eat three hundred million pounds of venison per year and yet not a single case of CWD to humans has been found.
Posted on 11/21/23 at 8:43 pm to JasonDBlaha
quote:
How can they diagnose him
Good response to you by Jose.
The confirmatory diagnosis is made at autopsy, looking at a slice of brain tissue under a microscope.
The widow of the man I knew who was suspected of having this disease that I posted about earlier, didn’t want to go through with an autopsy.
Posted on 11/21/23 at 8:46 pm to LSUA 75
quote:
I find it interesting that people get freaked out over an obscure ,rare disease such as CJD
Well apparently not that rare judging from this thread
Posted on 11/21/23 at 9:15 pm to Odysseus32
quote:
This is the wackiest response to this. “Everything causes cancer!”
You sitting in an office chair reading this? Turn it over. On the bottom, you will find a tag that says "This chair contains substances known to the state of California to cause cancer." Go into a parking deck next time you're out there. You will see a similar sign posted in the parking deck.
According to the state of California, pretty much everything does cause cancer.
Posted on 11/21/23 at 10:40 pm to G Vice
quote:
quote:
How can they diagnose him
Good response to you by Jose.
The confirmatory diagnosis is made at autopsy, looking at a slice of brain tissue under a microscope.
The widow of the man I knew who was suspected of having this disease that I posted about earlier, didn’t want to go through with an autopsy.
I have read that some doctors are spooked about handling prion related autopsies and want nothing to do with them. Even autoclaves aren't effective at sterilizing the surgical instruments, that's scary shite.
Posted on 11/21/23 at 11:06 pm to Rick9Plus
Doctors saying it’s spontaneous just means they have no fricking clue but what is telling to me is all you coonasses ITT having so many instances with this rare disease and you all eat squirrel brains like it’s the Great Depression.
Posted on 11/21/23 at 11:13 pm to JJ27
quote:
I had a good friend’s Dad pass away from it.
I don’t question any individual story in this thread, but the cumulative stories have to be mostly BS. There is simply no statistical way this many people on this board know someone who has passed away from it, unless you all know the same 2-3 people.
Posted on 11/22/23 at 12:19 am to slackster
Well I’m 72,if avg of 300 people die from it yearly,21,600 people have died from it during my lifetime.I’ve only known 1 person,my cousin that died first of this year.
I worked 31 years full time ICU,I only saw 1 case in all those years so it’s pretty rare.
Pt. I saw had it as a suspected diagnosis,confirmed by autopsy.
I doubt my cousin ever ate squirrel brains,her dad was a fisherman,never hunted.
I seriously doubt squirrels have anything but a miniscule chance of acquiring CJD,they aren’t congregant feeders like cows,sheep and deer.
As I said in an earlier post,the head was my favorite part of the squirrel,the cheek meat was the best of the squirrel and the brains are just good.It’s just what one gets used to.I know people that have eaten rattlesnakes and say they’re good but I could never bring myself to eat a snake.
I don’t know if brains are particularly nutritious but organs are the most nutritious part of a animal.The American Indians instinctively knew that and prized the organs,all the stuff we throw away or feed to the dogs they ate.
I worked 31 years full time ICU,I only saw 1 case in all those years so it’s pretty rare.
Pt. I saw had it as a suspected diagnosis,confirmed by autopsy.
I doubt my cousin ever ate squirrel brains,her dad was a fisherman,never hunted.
I seriously doubt squirrels have anything but a miniscule chance of acquiring CJD,they aren’t congregant feeders like cows,sheep and deer.
As I said in an earlier post,the head was my favorite part of the squirrel,the cheek meat was the best of the squirrel and the brains are just good.It’s just what one gets used to.I know people that have eaten rattlesnakes and say they’re good but I could never bring myself to eat a snake.
I don’t know if brains are particularly nutritious but organs are the most nutritious part of a animal.The American Indians instinctively knew that and prized the organs,all the stuff we throw away or feed to the dogs they ate.
Posted on 11/22/23 at 12:35 am to White Bear
quote:
Research has not proven a link from deer to humans to date.
I'm an idiot for saying that because I knew that. I just didn't know what CJD was
Posted on 11/22/23 at 1:05 am to Bjorn Cyborg
quote:
People also used to eat hogs-head cheese, which was pig brain. All brain related food products are illegal now.
I ate pig brain once at one of the many pig roasts we used to do, usually with head-on pigs- for the cheeks and ears.
Decades later and it's still got to be the most delicious meat I've ever eaten (hehe insert gay jokes), no seasoning, straight out of Wilbur.
Didn't know about enough about prion diseases for it to scare me at the time. But we were in the "probably shouldn't eat that brain" era of it.
So I'll give the squirrel brain fans a pass, especially pre internet.
Posted on 11/22/23 at 5:43 am to Tupelo
quote:
who knows what's in potted meat,etc
Diddy used to say it’s made out of lips, peckers and intestines.
Posted on 11/22/23 at 7:22 am to slackster
My uncle passed from it some years back. I have discussed it and CJD multiple times on here and the OB as it relates to CWD.
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