How should I approach this draft....

Get the best possible qb, 2 rb, 2 wr, and #1 def in the first 6 rounds. Its usually the suprise players that you pick towards the end of the draft that give you the points for victories. Also make sure you dont pick players with the same position with same bye week. That was a huge rookie mistake for me one time. I also find that TE's arent gonna put up too much, but if you get a kicker on a week offensive team, they will help out alot. Just a novice opinion.

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Get the best possible qb, 2 rb, 2 wr, and #1 def in the first 6 rounds.

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I like most of this..
I disagree on getting a Def in the first 6 rounds. Theres no use on getting a Def when there still is good players left.

If you have like 1-3 picks then get a RB, but if you have the bottom picks then get a good QB. QB will help you win big in a 2 QB league.

Don't take a defense or kicker until LATE!
Reason: You just take the defense playing Detroit, Cleveland, etc. that week. Same goes for the kicker. Just pick up one who is playing a bad defense.

With 2 QBs, you either want 2 good ones, or a stud and a steady one. David Garrard would be steady. Palmer will also stick around for a while. He could be a boom.

Don't take somebody more than a round early, even if you love them. Odds are that you can trade for them, and get what you feel are 2 better players.

With two starting QB spots in a 12 man league, I'm thinking of loading my bench up with QBs as well for trade value. There are only going to be 8 nonstarters in the league. I'm thinking grab 2 or 3 for the bench and watch the trade offers light up after week one.

Don't put too much into that theory. Some of the a-holes i play with think their team is god when they pick and put too much faith in that and will never trade.

Also those MF'ers are gonna want your stud qb for their #2-3 rb/wr. frick em and go get some players.