re: Johnson & Johnson 1 shot vaccine shows 66% efficacy, 85% v severe disease

JNJ, PFE, and MRNA - all likely pretty similar efficacy when it's all said and done.

Consider this:

-Mean age of JNJ trial participants = 69.9
-Mean age of MRNA trial participants = 51.4
-Median age of PFE trial of participants = 52.0 - keep in mind this is median, not mean. Also, 57% of participants were below the age of 55.

Also to consider:

-JNJ trial - Black/Latino/Native American percent of total participants = 73%
-MRNA trial - B/L/NA percent of total = 35%
-PFE trial - B/L/NA percent of total = 37% (study did not report NA numbers)

Finally consider geography:

-JNJ trial - 15% of participants were from South Africa
-MRNA trial - no South African participants noted in study
-PFE trial - 2% of participants were from South Africa

JNJ trial also had a higher incidence of patients with comoridities than that of PFE and MRNA.

Bottom line. Comparing studies is comparing apples and oranges as it is in this instance.

PFE

MRNA

JNJ