quote:
Dietary interventions have not been effective in the treatment of multiple sclerosis (MS). Here we show that periodic 3 day cycles of a fasting mimicking diet (FMD) are effective in ameliorating demyelination and symptoms in a murine experimental autoimmune encephalomyelitis (EAE) model. The FMD reduced clinical severity in all mice, and completely reversed symptoms in 20% of the animals. These improvements were associated with increased corticosterone levels and Treg cell number, reduced levels of pro-inflammatory cytokines, TH1 and TH17 cells, and antigen presenting cells (APCs). Moreover, the FMD promoted oligodendrocyte precursor cell regeneration and remyelination in axons in response to both EAE and cuprizone MS models, supporting its effects on both suppression of autoimmunity and remyelination. We also report preliminary data suggesting that a FMD or a chronic ketogenic diet are safe, feasible and potentially effective in the treatment of relapsing remitting multiple sclerosis (RRMS) patients

This study was done using an FMD, which Longo states provides the benefits of fasting without completely adopting a water only fast. An FMD is a five day dietary intervention where the user consumes 1000 calories day one, then ~700 (or less) or 30%-40% of ones daily caloric needs on days 2-5. It is also characterized by low or no animal protein as well. So, you are correct that caloric restriction in general triggers autophagy; however, the FMD is extreme caloric restriction for around a week. It is recommended once per month by Dr Longo, but that could be difficult to fit in for most people. I wonder if OMAD combined with limited animal protein (and likely reduced protein in general) would trigger similar results. I need to research the right macro ratios used in his “Prolon” FMD pack and apply that to an OMAD for a similar effect.

MS Mice Model - FMD