re: 30-06 core lock 150 grain

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That said, I would shoot a premium bullet if I was shooting deer with a .270wsm. It's a fast caliber that uses light bullets which isn't really what the core lock is designed for. I would use Nosler partition (if my gun shot them well), barns TSX, Nosler accubond,

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Agree.
Personally, I wouldn't use the Nosler BT in a magnum round like the 270 WSM. I think the NBT is not stout enough for a very high velocity round like the 270 WSM and would expect too much expansion and not enough penetration compared to the aforementioned controlled expansion rounds.

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do yall re-sight in after switching from round to round?

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Yup.

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I ain't got time for that in the middle of deer season.

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Sure you do. It doesn't take that long to sight in a gun when changing loads. Do it during the middle of the day when you're taking a break and you're not on the stand.