San Diego Game - 10/2

Stay anywhere within the trolley network, and take the trolley to qualcomm. Drops you off in the parking lot of the stadium, and beats the hassle of trying to drive. Best bet for hotels are in Mission Valley, near the stadium, or some where downtown (~15 min trolley ride each way)

What do you like to eat? San Diego has okay food, but it isn't the best food town. The gaslamp in downtown has about 100+ restaurants, of a wide variety. Yard house is your place if you are into craft beer (craft beer scene in SD is huge), Hodads is a few blocks away and one of the best burgers you will have in your life. There's also a wide variety of Brazilian steakhouses in the same area, if you want to spend some money.

The beaches are always nice in October, especially La Jolla cove if you want to make a 30 min drive. Balboa park, the zoo, and the multiple museums are also very nice.

Did you get tickets yet?

Stay downtown and hang out in the gaslamp. It's great.

It's a long trip to the stadium from there, but worth it. (I saw someone else mention a shuttle system, I haven't used it but if it exists, that's the way to go)

It's a great city, I'd stay downtown and take the trolley system, it's a train, to Qualcomm for the game. Downtown is cool but rent a car and get out off downtown, there's so much to do here. I'd just Google things to do in San Diego and take your pick.
I'm am looking forward to this game so much, every week the away fans take over in that stadium and it's our time.