quote:
The problem with heartguard is the dosage is too low. There are some dogs that can't handle the higher dosage. I find that my BMC cur and mutts don't seem to mind.

Now this could be a more reasonable argument. If heartworms in the deep south are developing resistance to ivermectin at the doses typically used in heartworm preventatives it is possible that a higher dose would be required for prevention.

quote:
Yeah it's not pure 100% Ivermectin.

ivomec isn't 100% ivermectin either. Which is a good thing b/c that would make it unstable and difficult to dose at a high concentration. It's a 1% solution (or 10mg/mL) that also contains other ingredients for stability and to make it safe for injection or oral administration.

Oral forms of ivermectin like pastes and chewable tablets also combine ivermectin with other ingredients for the same reasons.

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Posted by offshoretrash

Farmerville, La

Member since Aug 2008

10178 posts

Posted on 2/2/16 at 10:31 pm to AubieALUMdvm

quote:
Recent information has come to light that Heartgard may be only 95% effective, rather than 100% effective, in preventing heartworm infections. That means it will destroy 95% of heartworm larvae, not that 95% of dogs receiving Heartgard will remain heartworm-free.

The dosage of ivermectin used in Heartgard was the lowest found to be 100% effective at killing heartworm larvae when the product was originally approved. Since lower doses were less effective, it's possible that higher doses may continue to be 100% effective.

Higher doses of ivermectin are safe for all dogs except those with the MDR1 mutation. Dosages as high as 50 times the amount used to prevent heartworms are used to treat mites on dogs (demodectic mange). Very high dosages may also be problematic for dogs infected with Heartworms, and those being treated with Comfortis. See Ivermectin Sensitivity above for more information.

It may be best to double the amount of ivermectin you give your dogs in order to potentially provide better protection from heartworm infection. Again, this does not apply to dogs with the MDR1 mutation.

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