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re: Anyone ever heard of or taken Suboxone?
Posted on 10/7/15 at 3:25 pm to whit
Posted on 10/7/15 at 3:25 pm to whit
quote:
Buprenorphine
quote:
Buprenorphine is a semi-synthetic, highly lipophilic opioid derived from thebaine. Buprenorphine is a partial agonist at µ receptors; it has higher affinity for µ receptors but a lower activity at these receptors than the pure agonists. Buprenorphine is 25 to 50 times more potent than morphine, and the recommended intramuscular dose is 0.3 mg, which acts after 30 minutes and lasts for up to 8 hours. Extensive hepatic metabolism means that the bioavailability is low when given orally, but sublingual administration of 0.4mgs of buprenorphine is effective. The adverse effects are similar to morphine but as buprenorphine has very high affinity for µ receptors, it may be only incompletely reversed by naloxone. The major problem with buprenorphine is the high incidence of severe nausea and vomiting experienced especially by patients who are mobile.
TL:DR Gets you high as frick
Posted on 10/7/15 at 3:30 pm to Hardy_Har
quote:
Buprenorphine is a semi-synthetic, highly lipophilic opioid derived from thebaine. Buprenorphine is a partial agonist at µ receptors; it has higher affinity for µ receptors but a lower activity at these receptors than the pure agonists. Buprenorphine is 25 to 50 times more potent than morphine, and the recommended intramuscular dose is 0.3 mg, which acts after 30 minutes and lasts for up to 8 hours. Extensive hepatic metabolism means that the bioavailability is low when given orally, but sublingual administration of 0.4mgs of buprenorphine is effective. The adverse effects are similar to morphine but as buprenorphine has very high affinity for µ receptors, it may be only incompletely reversed by naloxone. The major problem with buprenorphine is the high incidence of severe nausea and vomiting experienced especially by patients who are mobile.
and the pills/strips they prescribe are 8MG, think about how much that is.
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