re: Looking at .22 Pistols.

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First group are basically trainer pistols IMHO. Second group is target pistols

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+1

And as for the Mark 3 and 22/45, the 22/45 means that it was designed to mimic the grip angle of John Moses Browning's iconic 1911 in 45. If you're used to a 1911 grip angle, it's better. If you like the over exaggerated grip angle of Glock pistols, the Mark 3 would be better. Both use essentially the same upper though.