re: What is the Most Effective OTC Medicine For A Cold?

Mucinex is good for cough.
For runny nose/congestion, I got the CVS brand "Severe Cold" stuff. Seemed to work well enough.

In case of stuffed-up nose, Afrin is a lifesaver. Nothing is more irritating than not being able to breathe through my nose, which then means I can't smell or taste. Stuff works like a charm, but you're not supposed to use it for more than 3 days.

I also take ColdEeze a lot. Not sure if it REALLY works, but even placebo effect is better than nothing when you get colds. I get them too often...