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I was more commenting on the very idea of "Can you imagine anyone else as Lecter?!?" as if that makes Hopkins essential to the character. He isn't and Cox was very good in his role as well.

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The point is well taken that the character had different roles in the different films and are definitely different incarnations of the character, and even from the source material.

Having said that, "Can you imagine anyone else as Lector?" is quite different from "Can you imagine anyone else as Lector in SOTL?", isn't it?

There are certain roles that are just tough to detach the actor's performance from the character itself - Deniro as Biddle, Samuel L. Jackson as Jules Winfield, Brando as Corleone - Hopkins as Lector (in SOTL) is just one of those performances.