re: Will LSU be able to Run the Ball?

To answer the question, in an intelligent manner, would require knowledge of Penn State's defense.
How does its D-line compare to Bama's? Linebackers to Florida's or Bama's? Secondary to Florida's?

Is PSU's defense big, strong, and fast?
Or just big and strong, e.g., tOSU?

LSU's biggest problem, besides having a dumb "Michigan Man" as head coach, is poor quarterback play. Jefferson couldn't find his arse with both hands, much less a wide open receiver. Opposing teams stack the box and beg Jefferson to attempt a pass, especially in the pocket, as opposed to a roll-out or run-pass option. LSU's coaches are calling plays like Jefferson is Drew Brees.
It's like polishing a turd.

LSU is EASY to defend and easily could have lost to Miss. State, Georgia, and Arkansas. If my math is right, that would result in a 6-6 record.

But, from what I hear, PSU's QB is pretty shitty himself.