re: Why are mice always the subject to experiments?

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Isn’t there some controversy in the scientific community amongst researchers about the mice that have been used in most studies? Like a good chunk of research is practically null and void because the mice used are all so closely related and have similar genetic defects and such, but since so much of science is already based upon those findings it can’t exactly be redone at this point.

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yes and no.

the big part of the debate is partly what you described. boiling it to basics, the population of mice used in research might be too specific. IE it doesnt represent a true biodiversity you would see naturally. I agree with that in a way. On the other hand when you are using mice you are usually at the early stages of development in whatever you are looking into. The core aspects of biology are still valid.

I do think diversity should be higher in most rodent research populations and the NIH is starting to put that into requirements for grant funding. To say all previous research is null and void is very much an overreach and when someone says that its a "ding ding" lights on to me they probably are anti-animal research in general.