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2006 SeasonHead Coach: Les Miles
Overall Record: 11-2 Conference Record: 6-2
Final Ranking: 3
| | Sep. 2 | Louisiana-Lafayette | W | 45-3 | Baton Rouge, LA | | Sep. 9 | Arizona | W | 45-3 | Baton Rouge, LA | | Sep. 16 | Auburn | L | 3-7 | Auburn, AL | | Sep. 23 | Tulane | W | 49-7 | Baton Rouge, LA | | Sep. 30 | Miss. State | W | 48-17 | Baton Rouge, LA | | Oct. 7 | Florida | L | 10-23 | Gainesville, FL | | Oct. 14 | Kentucky | W | 49-0 | Baton Rouge, LA | | Oct. 21 | Fresno State | W | 38-6 | Baton Rouge, LA | | Nov. 4 | Tennessee | W | 28-24 | Knoxville, TX | | Nov. 11 | Alabama | W | 28-14 | Baton Rouge, LA | | Nov. 18 | Ole Miss | W | 23-20 (OT) | Baton Rouge, LA | | Nov. 24 | Arkansas | W | 31-26 | Little Rock, AR | | Sugar Bowl | | Jan. 3 | Notre Dame | W | 41-14 | New Orleans, LA |
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