- My Forums
- Tiger Rant
- LSU Recruiting
- SEC Rant
- Saints Talk
- Pelicans Talk
- More Sports Board
- Fantasy Sports
- Golf Board
- Soccer Board
- O-T Lounge
- Tech Board
- Home/Garden Board
- Outdoor Board
- Health/Fitness Board
- Movie/TV Board
- Book Board
- Music Board
- Political Talk
- Money Talk
- Fark Board
- Gaming Board
- Travel Board
- Food/Drink Board
- Ticket Exchange
- TD Help Board
Customize My Forums- View All Forums
- Show Left Links
- Topic Sort Options
- Trending Topics
- Recent Topics
- Active Topics
Started By
Message
Big 4-year Wegovy study out...
Posted on 5/13/24 at 9:18 pm
Posted on 5/13/24 at 9:18 pm
quote:
New analyses of the longest clinical trial yet of the weight-loss drug Wegovy are shedding light on how quickly it helps people lose weight, how long they sustain that weight loss and how safe the medicine is over four years of use.
The analyses – of a trial called Select, whose results showed last year that Wegovy significantly reduced heart risk in addition to helping with weight loss – also suggest that the drug may protect the heart in ways beyond weight loss alone, researchers said, raising new questions about how the wildly popular medicines in this drug class should be used – and covered by insurers.
Even a Pennington doc quote in there somewhere.
LINK
This post was edited on 5/13/24 at 9:42 pm
2
Posted on 5/14/24 at 6:13 am to Big Scrub TX
quote:
whose results showed last year that Wegovy significantly reduced heart risk in addition to helping with weight loss – also suggest that the drug may protect the heart in ways beyond weight loss alone
Are they saying it has an effect on the heart that’s unrelated to the weight loss?
Because of course we’d expect reduced heart risk with weight loss.
Posted on 5/14/24 at 7:04 am to Earnest_P
quote:
Are they saying it has an effect on the heart that’s unrelated to the weight loss?
Yes. Attributed to reduction in overall chronic inflammation in the body which adversely effects heart and vascular health, which is now improved with use of this medication.
Posted on 5/14/24 at 7:32 am to Earnest_P
quote:
Are they saying it has an effect on the heart that’s unrelated to the weight loss?
Because of course we’d expect reduced heart risk with weight loss.
correct 20% reduction in heart related issues that are not attributed to any weight loss. essentially for those that didnt lose weight, still saw 20% reduction
study came out a while back, i didnt post it cause certain people on this board tend to shite on everything related to this medicine
but it helps
weight loss
blood sugar
heart
brain especially with impulse control
this class of drugs really is almost a miracle drug
if anyone wants some entertainment this morning, post this on the OT lounge
This post was edited on 5/14/24 at 7:33 am
Posted on 5/14/24 at 7:37 am to lsu777
quote:You really wanna kick that hornets nest?
anyone wants some entertainment this morning, post this on the OT lounge
quote:100%
class of drugs really is almost a miracle drug
Had one of the gym regulars I had never spoken a word to come up to me this AM and congratulate me on my progress. Felt good.
This post was edited on 5/14/24 at 7:40 am
Posted on 5/14/24 at 7:58 am to Uncle JackD
quote:
Had one of the gym regulars I had never spoken a word to come up to me this AM and congratulate me on my progress. Felt good.
thats awesome
quote:
You really wanna kick that hornets nest?
prolly not today for me, but later this week if work is slow....frick yea. those are always the best other than the travel ball threads.
Posted on 5/14/24 at 8:16 am to lsu777
quote:
weight loss
blood sugar
heart
Same can be said of proper diet, exercise, and healthy living habits. Its not unique to any drug. This can be done without them. How do I know this? We have the studies!!!!!!!!!
This post was edited on 5/14/24 at 8:17 am
Posted on 5/14/24 at 8:19 am to ronricks
quote:
Same can be said of proper diet, exercise, and healthy living habits. Its not unique to any drug. This can be dine without them. How do I know this? We have the studies!!!!!!!!!
you are right they can be
but diet doesnt produce 20% less heart issues in those that dont lose weight
and why are you so against living better through chemistry?
and lets say someone is already 12% bodyfat, eats a proper diet, lifts, gets their steps in, gets some zone 2 in.......guess what....glp1 class offers more benefits on top of those things and on top of supplements
its an antiaging drug in every way.
btw meant to ask you, why did carnivoreMD give up carnivore...asking legit question, havent had time to research.
Posted on 5/14/24 at 8:22 am to lsu777
I’m anxiously awaiting for you to post to the OT!
Posted on 5/14/24 at 8:46 am to lsu777
quote:
this class of drugs really is almost a miracle drug
COVID broke my faith in studies.
Posted on 5/14/24 at 8:48 am to lsu777
quote:
btw meant to ask you, why did carnivoreMD give up carnivore...asking legit question, havent had time to research.
I don't know who 'carnivoreMD' is. Some people like to add fruits etc. I eat blueberries, blackberries, or raspberries on occasion. Any diet be it strict carnivore, carnivore, ketovore, strict keto, AB30, etc. is better than the SAD. As we have discussed everyone is different. What works for you might not work for me and vice versa. There is no end all be all because we are all different. I tell people to try all the various ones for 30 days and then use trial and error to find out how you best respond and this will also be goal dependent as well:
-Some people will want to just lose weight and walk.
-Some people will want to lose weight and build some muscle.
-Some people will want to lose weight and do a total body re-comp building as much muscle as possible.
It just depends but whatever one chooses it is better than the artificial, fake, processed SAD. I advocate for people to just cut out processed foods and walk if they want to lose weight feel better etc. Walking is awesome and not everyone wants to go to a gym.
For me right now all that matters is metabolic, cardiovascular and immune health and all I care about is size of my waist which in turn will make shoulders, arms, chest, legs, etc look bigger. I do not care about 'strength' or 'size'.
The internet is loaded with people who for whatever reasons push different diets etc. I think there is a diet out there for everyone they just have to find it.
Posted on 5/14/24 at 9:11 am to ronricks
quote:
carnivoreMD
Paul Saladino
i agree with everything else you said except the strength part, but you also have built a huge base, everything else i agree with.
meant to ask too, have you been monitoring your cholesterol? how is it since you been carnivore full time a while
Posted on 5/14/24 at 9:20 am to Aubie Spr96
quote:
COVID broke my faith in studies.
i can understand that, but if you read the covid studies....they didnt actually say what most of the headlines try to portray.
plus that shite was a political issue, this isnt. read the data in the study, its legit
Posted on 5/14/24 at 9:35 am to lsu777
quote:
have you been monitoring your cholesterol? how is it since you been carnivore full time a while
Last bloods all cholesterol was in normal range. That however is approaching 6 months ago so no longer relevant. Will be going to have bloods done on second week of June as that will be over 60 days since I have started the boron/dhea protocol so that result is what I will also be interested in. I also cut out fish/krill oil supplementation back in February so will be interesting to see if that has had any impact. I don't 'feel' any different off them but that doesn't mean they were not doing some good.
Main thing I am excited to see is what if anything the boron/dhea has done. I have oily skin on face from the dhea that I did not have before and the boron is working with the morning wood being much more pronounced than before so I know they are both 'working' it is just to what extent? I will then re-evaluate and decide how 'long' to use them I have seen some people say 6 months, some a year, with 2 years being max and also - what happens when I go off of them? I will eventually need tRT there is no escaping it but I would like to continue with this route as long as I can 'naturally'. Also, I have posted before if my bloods are not good from the carnivore I will drop it immediately and re-evaluate and pivot to something else as my overall goal at this point is simply to be healthy even if I lose some muscle changing to a different diet I will be ok with that as I would rather have bloods being in line vs having 5 more pounds of muscle. Been a heck of a 2 and a half year journey so far.
Posted on 5/14/24 at 9:47 am to lsu777
quote:I thought it was a 20% decrease in heart risk for those that already had heart risks?
but diet doesnt produce 20% less heart issues in those that dont lose weight
But in any event - serious question - are we certain that diet does not produce similar reductions without weight loss? If this is tied to reducing inflammation, then certainly it must, right?
quote:With no tradeoff? Just seems like a free lunch.
and lets say someone is already 12% bodyfat, eats a proper diet, lifts, gets their steps in, gets some zone 2 in.......guess what....glp1 class offers more benefits on top of those things and on top of supplements
its an antiaging drug in every way.
Separate question on cholesterol: I'm still waiting to do my massive Marek panel, but I had some "regular" bloodwork done by my PCP. My cholesterol is still "high" (I think 264), but my tris are very low, tri/HDL is best ratio I've ever had (.66) and nothing else looks amiss. What say you?
Posted on 5/14/24 at 9:52 am to ronricks
quote:
I also cut out fish/krill oil supplementation back in February
can i ask why?
quote:
Will be going to have bloods done on second week of June as that will be over 60 days since I have started the boron/dhea protocol so that result is what I will also be interested in
interested in these results too.
as far as how long to stay on, there is no real limit so long as estrogen is in check
quote:
I will eventually need tRT there is no escaping it but I would like to continue with this route as long as I can 'naturally'
quote:
I will eventually need tRT there is no escaping it but I would like to continue with this route as long as I can 'naturally'
yea that was my issue. after the fertility treatment though i was sitting in the 702/80s and i really had zero choice based on how i felt
quote:
Also, I have posted before if my bloods are not good from the carnivore I will drop it immediately and re-evaluate and pivot to something else as my overall goal at this point is simply to be healthy even if I lose some muscle changing to a different diet I will be ok with that as I would rather have bloods being in line vs having 5 more pounds of muscle. Been a heck of a 2 and a half year journey so far.
if that is your goal, i have posted my get blood work perfect protocol. should look into the ones i mentioned. all can pretty much be taken for life and will greatly reduce chances of a stroke or heart attack.
Posted on 5/14/24 at 9:59 am to Big Scrub TX
quote:
thought it was a 20% decrease in heart risk for those that already had heart risks?
correct and that also did not lose weight from what i read
quote:
are we certain that diet does not produce similar reductions without weight loss? If this is tied to reducing inflammation, then certainly it must, right?
from the studies i have seen diet doesnt. almost every study i have seen something like 90% of the benefits came from the actual fat loss.
but to be fair, i dunno of any studies that are 4 years and collecting data like this to see if diet could play same role by reducing inflammation over a long period of time without weight loss
thing is, and we have discussed before, those that tend to be very low carb type diet for long periods, tend to lose weight naturally as they tend to lower calories without counting and its the only style of diet where the same people dont tend to lower caloric output.
so would be hard to have a study of any length where weight loss didnt come into play
quote:
With no tradeoff? Just seems like a free lunch.
depends on the dose but say on 1/2 of starting dose wouldnt be much but nasuea, diarhea and overall stomach discomfort for some.
quote:
Separate question on cholesterol: I'm still waiting to do my massive Marek panel, but I had some "regular" bloodwork done by my PCP. My cholesterol is still "high" (I think 264), but my tris are very low, tri/HDL is best ratio I've ever had (.66) and nothing else looks amiss. What say you?
so im not huge on making overall cholesterol the main focus, tend to focus on blood sugar, trig, and ratio but i do think its overall important.
i would recommend starting Nattokinase in the 4000iu morning and night for now and see how that affects your numbers after say 12 weeks.
Posted on 5/14/24 at 10:14 am to lsu777
quote:
can i ask why?
Just to see what happens. Rhonda Patrick has some interesting info out about high dose Omega 3's and anabolism/muscle building connection that I am interested in so after the blood work will get back on them.
quote:
as far as how long to stay on, there is no real limit so long as estrogen is in check
I was told I might be jumping the gun going after 60 days instead of 90 but I do not want to wait another 30 days I think at the dose I am using 18mg day of boron and 50mg of the dhea I will have some results. I've seen some say using dhea longer than 2 years might not be good but could simply be old wives tale? I do agree with you that along with creatine almost everyone who trains needs to be on some dose of boron everyday so that will not change. I am hoping by using this protocol that I have changed/improved my overall hormonal balance that is the main goal.
quote:
yea that was my issue. after the fertility treatment though i was sitting in the 702/80s and i really had zero choice based on how i felt
Yep no reason to do everything right (diet, exercise, sleep, etc) and just spin your wheels and feel like shite because of the t levels the very second I get that feeling I will be running to get on trt.
quote:
if that is your goal, i have posted my get blood work perfect protocol. should look into the ones i mentioned. all can pretty much be taken for life and will greatly reduce chances of a stroke or heart attack.
Trust me I have picked up bits and pieces from this forum as far as natural supplementation that I had zero clue about. When I was 'bodybuilding' my main expertise was all the anabolic/androgenic compounds when to take them how much to take etc, I knew very little about natural supplementation or even diet really because I was on so much shite especially the clen/hGH and insulin it didn't matter what I ate (provided I got the protein in) I was always shredded and I got out of the game before all the peptides came out there was just long igf-lr3 and a couple others which I never used and I still know nothing about them to this day. I've tried to purge my brain of all the anabolic information I had and I have forgotten a lot of it. I had all my log books with about 10 years of detailed use in them but I tore the pages up and threw them away I was worried if by chance I died even after I had been off for years that someone would find it and try to blame the use for my death
Posted on 5/14/24 at 10:28 am to ronricks
quote:
Trust me I have picked up bits and pieces from this forum as far as natural supplementation that I had zero clue about. When I was 'bodybuilding' my main expertise was all the anabolic/androgenic compounds when to take them how much to take etc, I knew very little about natural supplementation or even diet really because I was on so much shite especially the clen/hGH and insulin it didn't matter what I ate (provided I got the protein in) I was always shredded and I got out of the game before all the peptides came out there was just long igf-lr3 and a couple others which I never used and I still know nothing about them to this day. I've tried to purge my brain of all the anabolic information I had and I have forgotten a lot of it. I had all my log books with about 10 years of detailed use in them but I tore the pages up and threw them away I was worried if by chance I died even after I had been off for years that someone would find it and try to blame the use for my death
so i knew a lot in my younger days as i was looking to get on, then decided after 9/11 to go into army and forgot a lot of shite, then when started having issues started researching tons and tons on both sides of the isle.
i always focused on diet and natural supplementation and really digging into the actual studies not just random shite.
then for hormonal realized real quick, the science was easy to grasp but had to rely much much more on the steroid boards to really see what was happening as the papers didnt always match up.
i figure people are going to blame whatever they want anyways
cant beleive you were using insulin man, no wonder you so gun shy....you were all the way down the damn path.
i have seenplenty like you who abused in the past, go completely off then slowly come back but with an understanding that health comes first, very low doses, blood work always monitored, compounds like tren are no go etc etc etc
anyways if you need to help with anything you want to take off line can always email me
i know we argue a lot, but i actually do respect your opinion on things, but you are still an a-hole half the time
Posted on 5/14/24 at 10:55 am to lsu777
quote:
cant beleive you were using insulin man, no wonder you so gun shy....you were all the way down the damn path.
Brother it was dumb. I started using insulin at 19 at the time all that was available was Humulin R and it was otc at any pharmacy in Georgia. That was the fastest acting you could get at the time (Humalog didn't come out until later and was a gamechanger as it was so fast you could use it 3 times a day) and at first I was only (I say only it was tiny compared to what some were using at the time) using 10iu's post workout with 10 grams of creatine and I would drink a TwinLab carb fuel drink in the glass bottle mixed with 50 grams of protein in it so approx 100g carbs immediately post workout. I then upped it to 15 then 20 then 25 and even 30 iu's of insulin with the corresponding 10g carbs per iu in a drink mix. There were a few times more than once where I had to pull over or have my girlfriend pull over at a Subway and get me a large lemonade and a sandwich because something went wrong and I was beginning to sweat and almost pass out. Didn't phase me. Happened a few times in college as well. I kept using it because it freaking worked.
quote:
i have seenplenty like you who abused in the past, go completely off then slowly come back but with an understanding that health comes first, very low doses, blood work always monitored, compounds like tren are no go etc etc etc
I came off cold turkey which in retrospect was dumb. My training partner died on a Friday night in his sleep (he was also on opiates which I was not on and never did but it was also the anabolics as well)
I threw all my stuff away the very next day. Bagged it all up in grocery bags then put those into empty 5lb containers of protein I had and took to a gas station dumpster.
quote:
anyways if you need to help with anything you want to take off line can always email me
I'm going to post my bloods on here in a thread when I get them done. I think the numbers will show good and bad - the good it will show what someone can do if they stop training for years and then rededicate themselves naturally and the bad it will show numbers that likely no matter what I do will always be on the low or high end from abuse but I can still be healthy as long as I do what needs to be done through diet and exercise. My last visit to doctor he could not believe how far all my 'numbers' had come back to normal but it literally took years to reverse many of them some were reversed during the 6 years of not working out and being lazy and the others that were still bad were reversed from getting back into fitness and healthy lifestyle. It is possible to do this and I tell people this all the time unless you have completely blown everything out you can make a change and correct it and be healthy it just takes time, patience, and work.
This post was edited on 5/14/24 at 10:57 am
Page 1 of 4
Popular
Back to top
Follow TigerDroppings for LSU Football News