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re: 4 year long study on Wegovy/semaglutide shows heart benefits and safety

Posted on 5/15/24 at 9:26 am to
Posted by lsu777
Lake Charles
Member since Jan 2004
31478 posts
Posted on 5/15/24 at 9:26 am to
quote:

I'm not even talking about the GLP-1 drugs here. Not being for or against in this thread. Either way it can be fixed with or without them that is all I am saying. We both know this is the case. These folks likely need outside motivation and coaching on how to get started. I work with people just like this who get Bojangles on the way into the office for breakfast then Wendy's for lunch and get three 20oz cokes from the vending machine throughout the day all the while sitting in an office or cubicle for 8 hours a day which we both know might even be worse than all the fast food. These folks are doing it to themselves.


so do i and man a lot of these people just cant break it, especially those that have families. this is where i find the medicine helps

i find the medicine helps most in the family guy or lady that tends to have 2-3 drinks a night to wind down. thats the ones that tend to have the biggest turnaround on this medicine, not just in weight but across their whole life.
Posted by Lsupimp
Ersatz Amerika-97.6% phony & fake
Member since Nov 2003
78986 posts
Posted on 5/15/24 at 9:26 am to
People are narrative driven. So he doesn’t care if what he is saying applies to me or not. He just wants to make the point that a lot of obesity is behavioral driven. Which nobody is contesting. We’d have the same narratives forming if we were talking about curbing the desire to do drugs. People would weigh in with stories of their superior character because they never needed anything not to be a heroin addict. People like to crow and flamingo.

All I’m doing is using my experience as a non obese person who has this other great health side effect, to point out where this might be headed with other problems, compulsions, addictions.

Internet porn. Gambling. Phone addictions. Shopping addictions. People who want to do a religious fast. Alcohol. GI tract issues. So many things that quieting hormonal cravings and dopamine bursts can help with.
Posted by LSUGrrrl
Frisco, TX
Member since Jul 2007
33304 posts
Posted on 5/15/24 at 9:27 am to
quote:

His feelings, damnit.


I’m both amused and bemused by the cognitive block some people have when it comes to this topic. It’s like they refuse to learn any factual information presented and stick to what they’ve formulated in their own brains despite not being experts.
Posted by Robin Masters
Birmingham
Member since Jul 2010
30000 posts
Posted on 5/15/24 at 9:29 am to
quote:

Internet porn. Gambling. Phone addictions. Shopping addictions. People who want to do a religious fast. Alcohol. GI tract issues. So many things that quieting hormonal cravings and dopamine bursts can help with.


Whoa boy. One pill really does it all!

And I knew you frickers were born at night, I didn’t realize it was last night.

Good luck with your magic beans.
Posted by LSUGrrrl
Frisco, TX
Member since Jul 2007
33304 posts
Posted on 5/15/24 at 9:30 am to
quote:

All I’m doing is using my experience as a non obese person who has this other great health side effect, to point out where this might be headed with other problems, compulsions, addictions.

Internet porn. Gambling. Phone addictions. Shopping addictions. People who want to do a religious fast. Alcohol. GI tract issues. So many things that quieting hormonal cravings and dopamine bursts can help with.


All things that I’m very interested to track as more people begin to use these drugs.
Posted by Robin Masters
Birmingham
Member since Jul 2010
30000 posts
Posted on 5/15/24 at 9:31 am to
quote:

I’m both amused and bemused by the cognitive block some people have when it comes to this topic. It’s like they refuse to learn any factual information presented and stick to what they’ve formulated in their own brains despite not being experts.


Yeah, cause this time they’re actually telling the truth. All the other times they lied but THIS time they are totes on the level.
Posted by SlowFlowPro
Simple Solutions to Complex Probs
Member since Jan 2004
423679 posts
Posted on 5/15/24 at 9:31 am to
quote:

I’m both amused and bemused by the cognitive block some people have when it comes to this topic

On a surface level, I get it, but I also know that the same people likely reject all sorts of explanations for other personal pathologies. Like I imagine a great number of people who take ronricks's position on this also would call out a drug addict whose addiction was trauma-induced.

quote:

It’s like they refuse to learn any factual information presented and stick to what they’ve formulated in their own brains despite not being experts.

Welcome to the internet.
Posted by lsu777
Lake Charles
Member since Jan 2004
31478 posts
Posted on 5/15/24 at 9:31 am to
quote:

Whoa boy. One pill really does it all!

And I knew you frickers were born at night, I didn’t realize it was last night.

Good luck with your magic beans.


you really are a dense mother fricker huh?

either that or you are just too dumb to understand the hormonal response at the cellular level.

Posted by Semper Gumby
Member since Dec 2021
304 posts
Posted on 5/15/24 at 9:31 am to
2017 was when the first of these drugs was approved. You believe that’s long enough to truly document the affects, good or bad for long-term use for the masses?
Posted by Lsupimp
Ersatz Amerika-97.6% phony & fake
Member since Nov 2003
78986 posts
Posted on 5/15/24 at 9:31 am to
So assuming we both want fewer fatties let’s make a bet:

1 You harangue people about how slovenly and lazy they are.
2. I let them take these medications an learn behavioral modification techniques involving their relationship with food.
3. We reconvene in 5 years and see which approach reduced obesity.
Posted by BluegrassBelle
RIP Hefty Lefty - 1981-2019
Member since Nov 2010
99294 posts
Posted on 5/15/24 at 9:33 am to
quote:

All things that I’m very interested to track as more people begin to use these drugs.


I did a CEU a month or two ago that discussed utilizing semaglutide treatment in some eating disorders that has significantly reduced food rumination and has helped clients with ED reduce some negative food behaviors.

When you consider the mortality rate of eating disorders, it’s possible these drugs can save lives outside of basic weight loss.
This post was edited on 5/15/24 at 9:34 am
Posted by SlowFlowPro
Simple Solutions to Complex Probs
Member since Jan 2004
423679 posts
Posted on 5/15/24 at 9:34 am to
quote:

either that or you are just too dumb to understand the hormonal response at the cellular level.

This upsets his emotional state because it doesn't conform to his ignorant (yet structured) preconceived worldview.
Posted by lsu777
Lake Charles
Member since Jan 2004
31478 posts
Posted on 5/15/24 at 9:34 am to
quote:

2017 was when the first of these drugs was approved. You believe that’s long enough to truly document the affects, good or bad for long-term use for the masses?


for fatloss. they were approved in 2005 for diabetes.

been studied since the late 70s/early80s.

quote:

The FDA approved the first GLP-1 receptor agonist exenatide in 2005. The oral semaglutide tablet was approved by the FDA in 2019.
This post was edited on 5/15/24 at 9:36 am
Posted by SlowFlowPro
Simple Solutions to Complex Probs
Member since Jan 2004
423679 posts
Posted on 5/15/24 at 9:34 am to
quote:

2017 was when the first of these drugs was approved.


For this specific use.

They've been used for diabetes for almost 20 years.
Posted by LSUGrrrl
Frisco, TX
Member since Jul 2007
33304 posts
Posted on 5/15/24 at 9:34 am to
Breaking the dopamine addiction many people formed from eating bad foods is huge. Same reason it can help in so many other areas.
Posted by Prominentwon
LSU, McNeese St. Fan
Member since Jan 2005
93773 posts
Posted on 5/15/24 at 9:35 am to
quote:

Good luck with your magic beans.


Here’s a simple search for MAGIC BEANS of the last 50 years.

quote:

1. Penicillin (1940s): One of the first antibiotics, revolutionizing the treatment of bacterial infections.
2. Oral Contraceptives (1960s): Provided women with control over their reproductive health.
3. Insulin (1920s): Essential for managing diabetes, enabling millions to live with the condition.
4. Statins (1980s): Lower cholesterol and reduce the risk of heart disease, saving countless lives.
5. Antiretroviral Therapy (1990s): Dramatically improved the prognosis for HIV/AIDS patients.
6. Proton Pump Inhibitors (1980s): Treat gastroesophageal reflux disease (GERD) and peptic ulcers, improving digestive health.
7. Selective Serotonin Reuptake Inhibitors (SSRIs) (1980s): Revolutionized the treatment of depression and anxiety disorders.
8. Anti-TNF Drugs (1990s): Used to treat autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease.
9. Direct-acting Antiviral Drugs (2010s): Highly effective in treating hepatitis C, leading to cure rates exceeding 95%.
10. Immune Checkpoint Inhibitors (2010s): Transformative for cancer treatment, activating the immune system to fight cancer cells.



All these people with all these other health issues like these should have just shut up and went to lift some weights, I suppose.


Why can’t this medicine (GLP-1) be amongst this list?
This post was edited on 5/15/24 at 9:38 am
Posted by Semper Gumby
Member since Dec 2021
304 posts
Posted on 5/15/24 at 9:36 am to
My argument is not moralistic at all. I am skeptical of the safety in long-term use.
Posted by ronricks
Member since Mar 2021
7103 posts
Posted on 5/15/24 at 9:37 am to
quote:

1 You harangue people about how slovenly and lazy they are.

If they fit that description I will.
quote:

I let them take these medications an learn behavioral modification techniques involving their relationship with food.

I have not made one single negative statement for or against these medications in this thread. I've been neutral. Now, on the H&F forum I have posted other thoughts/opinions on them but have specifically stayed out of that in this particular thread.
quote:

We reconvene in 5 years and see which approach reduced obesity.

Unless actual lifestyle changes are made neither will work long term. There is no magic pill or potion. You have to want to do it.
Posted by LSUGrrrl
Frisco, TX
Member since Jul 2007
33304 posts
Posted on 5/15/24 at 9:38 am to
quote:

2017 was when the first of these drugs was approved. You believe that’s long enough to truly document the affects, good or bad for long-term use for the masses?


For weight loss. Same drugs have been used all the way back to early 80’s. This is just a new use for an old drug.
Posted by SlowFlowPro
Simple Solutions to Complex Probs
Member since Jan 2004
423679 posts
Posted on 5/15/24 at 9:38 am to
quote:

So assuming we both want fewer fatties let’s make a bet:

1 You harangue people about how slovenly and lazy they are.
2. I let them take these medications an learn behavioral modification techniques involving their relationship with food.
3. We reconvene in 5 years and see which approach reduced obesity.


He's trying to morph this conversation into one based around a conception of honor.

Ole boy needs to watch Harakiri (either the original or remake)
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