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First US coronavirus patients being treated with plasma therapy
Posted by Jbird on 4/2/20 at 8:48 am40
My Doc says this is the one she believes will ultimately be the main one.
Experimental treatments of coronavirus patients with plasma from recovered patients has begun in New York and Houston after the FDA approved such efforts.
The effectiveness of the treatment is unknown but the FDA approved it as a treatment on March 24, giving researchers the option to request emergency authorization to test the procedure. Methodist Hospital in Houston began soliciting donors Friday, performing the first transfusions for a patient the next day.
The approach, known as convalescent plasma, echoes an approach used for both the 1918 flu pandemic and the 2002 SARS outbreak, and has shown promising early signs in treatment of Chinese patients.
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“Convalescent serum therapy could be a vital treatment route because, unfortunately, there is relatively little to offer many patients except supportive care,” Eric Salazar, principal investigator in the Department of Pathology and Genomic Medicine at the Houston Methodist Hospital and Research Institute, told USA Today.
Michael Joyner, a professor of anesthesiology at the Mayo Clinic in Rochester, Minn., noted that experts do not expect the treatment to have a "Lazarus-like effect on the really ill," but said “what's more likely is that the slope of the patient's decline will gradually slow and that they can be weaned off of ventilation.”
At this stage, the donations are from people who have recovered after exposure to or infection with the virus about three weeks ago, which appears to be the timeframe in which human bodies develop a strong immune response to the coronavirus. The National COVID-19 Convalescent Plasma Project has posted a protocol for clinical trials on its site.
Ania Wajnberg, an internist at Mount Sinai Medical Center in New York City who is directing its Serum Antibody program, told USA Today that nearly everyone who has learned they are eligible for donation through the Plasma Project’s website has offered to help. LINK
Experimental treatments of coronavirus patients with plasma from recovered patients has begun in New York and Houston after the FDA approved such efforts.
The effectiveness of the treatment is unknown but the FDA approved it as a treatment on March 24, giving researchers the option to request emergency authorization to test the procedure. Methodist Hospital in Houston began soliciting donors Friday, performing the first transfusions for a patient the next day.
The approach, known as convalescent plasma, echoes an approach used for both the 1918 flu pandemic and the 2002 SARS outbreak, and has shown promising early signs in treatment of Chinese patients.
ADVERTISEMENT
“Convalescent serum therapy could be a vital treatment route because, unfortunately, there is relatively little to offer many patients except supportive care,” Eric Salazar, principal investigator in the Department of Pathology and Genomic Medicine at the Houston Methodist Hospital and Research Institute, told USA Today.
Michael Joyner, a professor of anesthesiology at the Mayo Clinic in Rochester, Minn., noted that experts do not expect the treatment to have a "Lazarus-like effect on the really ill," but said “what's more likely is that the slope of the patient's decline will gradually slow and that they can be weaned off of ventilation.”
At this stage, the donations are from people who have recovered after exposure to or infection with the virus about three weeks ago, which appears to be the timeframe in which human bodies develop a strong immune response to the coronavirus. The National COVID-19 Convalescent Plasma Project has posted a protocol for clinical trials on its site.
Ania Wajnberg, an internist at Mount Sinai Medical Center in New York City who is directing its Serum Antibody program, told USA Today that nearly everyone who has learned they are eligible for donation through the Plasma Project’s website has offered to help. LINK
re: First US coronavirus patients being treated with plasma therapyPosted by Homesick Tiger on 4/2/20 at 8:50 am to Jbird
Makes sense to me. You actually take venom from a snake to treat a snake bite so this would seem plausible also.
re: First US coronavirus patients being treated with plasma therapyPosted by ProjectP2294 on 4/2/20 at 8:50 am to Jbird
So is this basically allowing the antibodies in the blood of the recovered people to help fight the virus in the receiver? Or could this be used proactively to help prevent someone from getting sick in the first place?
re: First US coronavirus patients being treated with plasma therapyPosted by uppermidwestbama on 4/2/20 at 8:50 am to Jbird
Most likely will be the main initial treatment since it's from recovered persons.
How long it will take this to be done on a large scale I have no clue.
How long it will take this to be done on a large scale I have no clue.
quote:
My Doc says this is the one she believes will ultimately be the main one.
I have shared parts of this in different threads -- my wife knows a woman that tested positive for the Chinese Flu and got admitted to UAB as part of a trial for he Trump Pills
she recovered 100% & now tests negative -- NOW, this same woman is part of a new study at UAB! They are using her plasma for a study to develop an anti-body and or a vaccine
it is looking like we are actually getting closer to solving the problem in an amazingly fast time frame...
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re: First US coronavirus patients being treated with plasma therapyPosted by Jbird on 4/2/20 at 8:52 am to ProjectP2294
quote:This initially.
So is this basically allowing the antibodies in the blood of the recovered people to help fight the virus in the receiver?
quote:This in the future.
Or could this be used proactively to help prevent someone from getting sick in the first place?
re: First US coronavirus patients being treated with plasma therapyPosted by WildcatMike on 4/2/20 at 9:07 am to Jbird
Good luck supplying this for of treatment. A bag of IVIG is over $40,0000 and it takes over 7 years to produce it. The spinning process is extensive.
re: First US coronavirus patients being treated with plasma therapyPosted by tankyank13 on 4/2/20 at 9:12 am to ProjectP2294
Antibodies have multiple purposes. They deactivate the pathogen(virus), while also labeling it for destruction by other parts of the immune system
re: First US coronavirus patients being treated with plasma therapyPosted by Jbird on 4/2/20 at 9:20 am to WildcatMike
re: First US coronavirus patients being treated with plasma therapyPosted by tankyank13 on 4/2/20 at 9:25 am to WildcatMike
quote:
A bag of IVIG is over $40,0000 and it takes over 7 years to produce it.
The cost of IGG in a hospital setting, yes. Therapeutic treatment from an infusion center, it’s not that much, more like 5-10k.
And a pool of IGG takes a year to manufacture. That’s from donation to patient. That’s because it takes up to 20k donations.
This should not take that long because it’s only for the specific antibody. Just a thought.
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