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Started By
Message
re: GLP-1 Drugs Can Be Used First for Weight Loss Says American College of Cardiology
Posted on 6/24/25 at 10:26 pm to OKBoomerSooner
Posted on 6/24/25 at 10:26 pm to OKBoomerSooner
quote:
Nothing brings out the bitter and utterly fricking retarded takes like a drug that helps people lose weight. It’s the most amazing thing.
I can give you all sorts of shite that will make you lose weight, doesn’t mean it’s good for you.
And don’t tell me GLP-1’s have been around for decades. The same people that say that told you mRNA vaccines have been around since the 80s and push the standard American diet.
Let me know when we trust those people and when we don’t, considering their the same people
1
Posted on 6/24/25 at 10:27 pm to SallysHuman
I actually remember now. Big Jay Oakerson said it on "the Bonfire" a while back
He said his doctor told him that something the muscles use or produce can "eat up" (his words) your bones if your muscles aren't in use
Nothing high impact or tremendous. He has to do some light workouts a few times a week
He said his doctor told him that something the muscles use or produce can "eat up" (his words) your bones if your muscles aren't in use
Nothing high impact or tremendous. He has to do some light workouts a few times a week
Posted on 6/24/25 at 10:27 pm to dupergreenie
quote:
We also bang nothing lower than a 9…..
And get so many blow jobs they give some away.
Posted on 6/24/25 at 10:29 pm to Roaad
quote:
Roaad
Damn dude... I'm catching you errwhere tonight!
That bone thing is scary- my mom's on the shot, I'll have to ask her tomorrow if she's aware of bone issues and how to prevent them.
Posted on 6/24/25 at 10:30 pm to Mingo Was His NameO
quote:
quote:These drugs are one of the biggest achievements in the world. You have people who are destined for long-term poor health outcomes changing their life outlook by taking a simple shot weekly. OxyContin was going to eliminate pain forever and the Covid vaccine was going to eliminate Covid and has no side effects…. Oops
Option 1
Person stays 33% or more over their healthy weight. Suffers major health problems. Can never get over the hump to get to a healthy weight.
Option 2
Person takes shot. Loses 25% of their body weight over a year. Now has eliminated the major health concerns they were at risk for being obese. May have some side effects from drug. May have to stay on some level of dose long term. May not be on diabetic medication. May not be on cholesterol medication. May not be on a CPAP. May live 5-10+ years longer.
This is the absolute stupid argument we are in about these drugs.
Posted on 6/24/25 at 10:31 pm to Colonel Flagg
quote:
Option 1 Person stays 33% or more over their healthy weight. Suffers major health problems. Can never get over the hump to get to a healthy weight. Option 2 Person takes shot. Loses 25% of their body weight over a year. Now has eliminated the major health concerns they were at risk for being obese. May have some side effects from drug. May have to stay on some level of dose long term. May not be on diabetic medication. May not be on cholesterol medication. May not be on a CPAP. May live 5-10+ years longer.
The fact you think these are the only two options is really fricking pathetic and sad
Posted on 6/24/25 at 10:32 pm to RLDSC FAN
What happens when someone stops taking this? Is it a lifetime commitment to have to take weight loss medication?
Posted on 6/24/25 at 10:35 pm to tigergirl10
quote:
What happens when someone stops taking this? Is it a lifetime commitment to have to take weight loss medication?
I know of one chick, like my cousin-in-law, that was quite rotund... did the shot, lost the weight, quit the shot and actually maintained her weight loss.
I don't really know personally more than two people that have done it- the other just started last month.
Posted on 6/24/25 at 10:37 pm to SallysHuman
To be clear, she needs to listen to her doctor.
I don't know shite. I am just a rando in the internet
Was only relaying what I heard
I don't know shite. I am just a rando in the internet
Was only relaying what I heard
Posted on 6/24/25 at 10:38 pm to Roaad
quote:
Isn’t there evidence that if you don’t do some exercise while on GLP, you will get bone decay or degradation of some sort.
Short answer—I don’t know about bone decay specifically, but you’ll lose lean mass to some degree whenever you lose weight. Not weight training will result in a substantially worse ratio of fat loss to lean mass loss.
Long answer—I haven’t taken GLP-1s, but I took something similar to help me get started. At first I was a lazy frick and didn’t do any exercise, and lost a bunch of weight with basically zero effort. All I did was watch calories (and not even very closely). As I started losing weight less quickly, and just as importantly after I saw tangible results that I could trust, I started weight training and exercising regularly and stepped up my effort and diligence across the board. The end result is that I basically accidentally experimented with the function of a similar weight loss drug with and without exercise. And fortunately I tracked a bunch of biometric data as I did, so I could compare results.
When I wasn’t lifting, I lost weight in a ratio of 70% excess fat, 30% lean mass (which includes stuff like water weight, not just bone/muscle mass, but obviously had some of that too). Once I started lifting the ratio improved to 91% excess fat / 9% lean mass.
So two takeaways…
(1) Yes, you’ll have some lean mass loss, which could include bone mass. But this is a risk with any weight loss regimen and not specific to a drug. Our bodies aren’t perfect machines that only burn fat when we’re in a caloric deficit.
(2) That said, it’s obviously not equal, and taking a weight training regimen seriously alongside it will drastically reduce your rate of lean mass loss.
It’s just a tool like anything else at the end of the day. It’s only as good as its user is smart with it. If you misuse it and/or don’t understand it, you won’t get good long-term results. If you understand it and have a plan, you can literally save your life with it.
Posted on 6/24/25 at 10:39 pm to Mingo Was His NameO
quote:
The fact you think these are the only two options is really fricking pathetic and sad
It basically makes the person feel full so they eat smaller portions.
I would wager the vast majority of people put more harmful shite in their body than this drug everyday. People are arguing for people not doing it because it is viewed as cheating.
This would be like shaming someone for taking something to get them to quit smoking a pack or more of cigarettes a day. Why would anyone be against that?
Posted on 6/24/25 at 10:39 pm to Mingo Was His NameO
quote:
The fact you think these are the only two options is really fricking pathetic and sad
Maintaining weight and health requires maintenance but can be done maybe relatively easily.
Losing 30-300lbs is a good bit harder... made harder by amount of weight and age, also factoring in other health conditions brought on by obesity.
The Shot shouldn't be the only tool in the bag... but I truly don't understand the resistance to having that tool available.
Posted on 6/24/25 at 10:40 pm to BottomlandBrew
quote:These medications are like $1400 a month.
my healthcare premiums less because there are less fat people, then let's do it.
Posted on 6/24/25 at 10:41 pm to Mingo Was His NameO
As big of a douche as you are for as tiny as you are, it pains me to agree with you on this. But have a rare upvote.
Posted on 6/24/25 at 10:41 pm to Mingo Was His NameO
quote:
And don’t tell me GLP-1’s have been around for decades
Glucagon-like peptide-1 (GLP-1) receptor agonists go back at least 20 years to FDA approval of exenatide.
Posted on 6/24/25 at 10:42 pm to SallysHuman
quote:
Losing 30-300lbs is a good bit harder..
30, no. 300 yes
quote:
I truly don't understand the resistance to having that tool available.
You don’t understand the resistance to MORE dependency on pharmaceuticals?
If you are morbidly obese to the point of not being mobile, sure do whatever. If you are 280lbs, get up off your fat arse and eat right, get sunlight, exercise, and fix your sleep. Stop depending on pharmaceutical companies to keep you alive.
Posted on 6/24/25 at 10:44 pm to slackster
quote:
Glucagon-like peptide-1 (GLP-1) receptor agonists go back at least 20 years to FDA approval of exenatide.
Just like mRNA vaccines, adderall, and prescription pain killers. Those have all worked out great
Posted on 6/24/25 at 10:44 pm to tigergirl10
quote:
What happens when someone stops taking this? Is it a lifetime commitment to have to take weight loss medication?
Lifetime, no. But you need to be on it for more than a couple of months.
Most of the “failure” stories involve people who just take it because it’s trendy and they want to lose 20 lbs for aesthetic reasons with as little effort as possible. It works pretty well for that, and they drop it in 2-3 months. But that’s not long enough for them to develop better habits, and they don’t actually calorie count (or if they do they drop it after a week when the scale shows they lost 3 lbs). They’re basically just relying on the drug to satiate them without changing anything long-term. So they lose the weight, but nothing’s really changed, they start getting hungrier again like they used to, they begin eating like they used to, and next thing you know, it’s all back.
You need to stay on it for much longer… I’m no doctor and I know everyone is different, but I’d wager at least 9 months, probably a year or more. Long enough to drop some very serious weight (40+ lbs) and to reprogram your body’s expectations about food. You don’t see these rebound cases as often when the weight loss is more dramatic, because it takes a lot longer, and the people losing that much weight typically pick up better habits along the way. (I guess it’s possible to rebound after losing like 80 lbs or whatever, but that’s pretty clearly user error or some other freak confounding factor IMO.)
Posted on 6/24/25 at 10:44 pm to Colonel Flagg
quote:I'd rather people not die, regardless of cheating.
People are arguing for people not doing it because it is viewed as cheating.
But still, the root of how a fat frick became a fat frick has to be addressed, or they will become a fat frick again.
Lifelong reliance on this drug can't be the answer
I mean, we all agree this is true, right?
Posted on 6/24/25 at 10:45 pm to Roaad
quote:
To be clear, she needs to listen to her doctor.
Her doctor refused to prescribe it... he's young, fit and never had a weight problem... totally didn't get the issues of a post menopausal female with 30-40lbs to get off. She's on telehealth for it.
I did send her the article from the OP and told her to show her GP, in hopes he'd help her manage her weight loss instead of making her go internet doc shopping for it... I guess we'll see. She WANTS her doc's oversight but he's just not into the shots, I guess.
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