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Does creatine supplementation and an high protein diet affect blood work numbers?

Posted on 11/20/25 at 12:56 pm
Posted by 3HourTour
A whiskey barrel
Member since Mar 2006
21863 posts
Posted on 11/20/25 at 12:56 pm
My doctor thinks I have something wrong with my kidneys based on BUN and eGFR levels. Told me to drink a gallon of water a day and go back in 8 weeks for more blood work. I tend to drink that amount of water daily as it is.
Posted by TooFyeToFly
Atlanta, Georgia
Member since Nov 2012
2063 posts
Posted on 11/20/25 at 2:27 pm to
Yes. Creatine can absolutely throw off your test results because creatinine is processed in the kidneys and liver. However, it isn't cause for concern because it has more to do with how standard blood tests use certain markers to flag potential issues. Creatine can elevate those markers, but it is harmless. I'd definitely flag this for your doctor whenever you get a blood test.
Posted by TigerTatorTots
The Safeshore
Member since Jul 2009
82049 posts
Posted on 11/20/25 at 3:08 pm to
Yes my BUN has been high for a decade and my doc attributes it to my creatine intake and high protein diet
Posted by Uncle JackD
Member since Nov 2007
59436 posts
Posted on 11/20/25 at 3:15 pm to
Cystatin C is a more accurate kidney function marker if your eating a really high protein diet or have more muscle mass than average.

I actually tossed one in on this morning lab draw.
This post was edited on 11/20/25 at 3:16 pm
Posted by TigerTatorTots
The Safeshore
Member since Jul 2009
82049 posts
Posted on 11/20/25 at 3:22 pm to
You still using Fitnomics? I used them earlier this year when I did a 100+ marker panel but then cancelled the sub because I knew it would be 6 months before I needed them again. Trying to compare just going the quest route or if the subscription model is a better deal
Posted by Uncle JackD
Member since Nov 2007
59436 posts
Posted on 11/20/25 at 3:30 pm to
quote:

You still using Fitnomics?
I am. I just keep the subscription rolling and draw labs quarterly. Probably excessive but good peace of mind for me.

They should have a Black Friday sale coming soon. I usually buy them then when it’s 20% off since the req form is good for 180 days
This post was edited on 11/20/25 at 3:32 pm
Posted by whiskey over ice
Member since Sep 2020
3677 posts
Posted on 11/20/25 at 7:13 pm to
Posted by StreamsOfWhiskey
The Woodlands, TX
Member since Jun 2013
829 posts
Posted on 11/25/25 at 12:07 am to
Yes, it can affect it. I’ve been eating low carb/high protein/fat for over 20 years. I also take creatine and I lift 5x/week. Stop the creatine a week before your test and I bet you will test normal. It will give off false positives.
Posted by Willie Stroker
Member since Sep 2008
15652 posts
Posted on 12/2/25 at 6:41 pm to
If you get off of creatine for 10 days before your next blood test, the effect of it on your test results should return to normal.
Posted by bayouvette
Raceland
Member since Oct 2005
5579 posts
Posted on 12/3/25 at 1:29 pm to
Gonna test this theory out in a couple weeks
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